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Epigenetics and Peripheral Artery Disease
Current Atherosclerosis Reports, 2016The term epigenetics is usually used to describe inheritable changes in gene function which do not involve changes in the DNA sequence. These typically include non-coding RNAs, DNA methylation and histone modifications. Smoking and older age are recognised risk factors for peripheral artery diseases, such as occlusive lower limb artery disease and ...
Golledge, Jonathan +4 more
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The Lancet, 2001
Lower extremity peripheral arterial disease (PAD) most frequently presents with pain during ambulation, which is known as "intermittent claudication". Some relief of symptoms is possible with exercise, pharmacotherapy, and cessation of smoking.
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Lower extremity peripheral arterial disease (PAD) most frequently presents with pain during ambulation, which is known as "intermittent claudication". Some relief of symptoms is possible with exercise, pharmacotherapy, and cessation of smoking.
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Cardiology Clinics, 2011
co m The last decade has seen a tremendous surge of interest in peripheral arterial disease (PAD). The prevalence of multiple risk factors, chronic nature of disease, the nonspecificity of symptoms, and lackof adequate treatment optionshaveall contributed to the large burden of disease, which is frequently unrecognized.
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co m The last decade has seen a tremendous surge of interest in peripheral arterial disease (PAD). The prevalence of multiple risk factors, chronic nature of disease, the nonspecificity of symptoms, and lackof adequate treatment optionshaveall contributed to the large burden of disease, which is frequently unrecognized.
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Antioxidants in Peripheral Arterial Disease
Current Drug Targets, 2003Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggested a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good
F, Violi +3 more
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Cilostazol and peripheral arterial disease
Expert Opinion on Pharmacotherapy, 2008Peripheral arterial disease is both common and disabling. Contemporary management of peripheral arterial disease is multimodal, encompassing both medical and interventional treatments. Cilostazol (Pletal), a 2-oxoquinolone derivative, is currently licensed in the UK for the treatment of patients with intermittent claudication to improve their walking ...
Lyndsay, Pearce +3 more
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Biomarkers in Peripheral Arterial Disease
Trends in Cardiovascular Medicine, 2009Patients who have peripheral arterial disease (PAD) have a high incidence of cardiac morbidity and mortality. There have been numerous biomarkers described to assess cardiovascular risk, but few are part of routine clinical practice. Currently, the key biomarkers that improve risk stratification in patients with PAD are cardiac troponins, C-reactive ...
James C, Thomas +5 more
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Cryoplasty for peripheral arterial disease
Cochrane Database of Systematic Reviews, 2013Percutaneous balloon angioplasty is an endovascular technique for restoring blood flow through an artery that has become narrowed or blocked by atherosclerosis. Narrowing of the artery following angioplasty (restenosis) is the major cause of long-term failure. Cryoplasty offers a different approach to improving long-term angioplasty results.
James E, McCaslin +2 more
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Footcare and peripheral arterial disease
Journal of Vascular Nursing, 2023Changes in the feet occur with age which can cause pain and other foot pathologies that can lead to falls, foot ulcers and amputation. Some older adults may have difficulty doing foot hygiene due to physical or mental decline such as body habitus, poor vision, arthritic problems to mention a few.1 The presence of PAD creates an increased risk of foot ...
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Treatment of peripheral arterial disease
Clinical Cornerstone, 2002Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis strongly associated with cardiovascular (CV) morbidity and mortality. Approximately 12% of the US adult population is affected. Despite its prevalence, the disease has received little attention from clinicians.
Judith G, Regensteiner, William R, Hiatt
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Angiogenesis in peripheral arterial disease
Current Opinion in Pharmacology, 2018Peripheral arterial disease (PAD) refers to narrowing of the peripheral arteries and atherosclerosis is the most important cause. In patients with PAD, revascularization is the preferred therapeutic strategy; nonetheless several patients are not deemed candidates for it due to advanced disease or several comorbidities.
Chakradhari Inampudi +3 more
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