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Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Lipidomic Signature of Abdominal Aortic Aneurysm and Peripheral Artery Disease. [PDF]

J Proteome Res
Ferreira HB, van Merrienboer T, Guerra IMS, Melo T, Yeung KK, Ayyalasomayajula V, Trindade F, Nogueira-Ferreira R, Leite-Moreira A, Goracci L, Ferreira R, Domingues MR, Dias-Neto M, VASCUL-AID Consortium.   +13 more
europepmc   +1 more source

Effect of metformin in a novel experimental model of peripheral artery disease. [PDF]

Clin Sci (Lond)
Krishna SM, Moxon J, Kraeuter AK, Golledge J.   +3 more
europepmc   +1 more source

Duration of Supervised Exercise Necessary for Meaningful Improvement in Peripheral Artery Disease. [PDF]

J Am Heart Assoc
McDermott MM, Zhang D, Zhao L, Polonsky T, Ferrucci L, Ho KJ, Kibbe MR, Guralnik JM, Criqui MH, Tian L.   +9 more
europepmc   +1 more source

Nicotinamide N-methyltransferase inhibition improves limb function in experimental peripheral artery disease. [PDF]

Physiol Rep
Dong G, Choi J, Li Y, Muller DC, Li Z, Luo YE, Ryan TE.   +6 more
europepmc   +1 more source

Multiomics Analysis of Skeletal Muscle Identifies Dysregulation of Hypoxia-Induced Genes in Peripheral Artery Disease. [PDF]

J Am Heart Assoc
Ismaeel A, Fletcher E, Papoutsi E, Thomas NT, Bohannon WT, Pipinos II, Wen Y, Miserlis D, Koutakis P.   +8 more
europepmc   +1 more source

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Peripheral Arterial Disease

Endocrinology and Metabolism Clinics of North America, 2014
Peripheral arterial disease (PAD) is an atherosclerotic-driven condition that remains underdiagnosed and undertreated. In diabetic patients, PAD begins early, progresses rapidly, and is frequently asymptomatic, making it difficult to diagnose. Strict management of the metabolic instigators and use of screening techniques for PAD in diabetes can ...
Janice V, Mascarenhas, Mostafa A, Albayati, Clifford P, Shearman, Edward B, Jude   +3 more
  +6 more sources

Peripheral arterial disease

Nursing, 2012
Peripheral arterial disease (PAD) affects a considerable percentage of the population. The manifestations of this disease are not always clinically overt. As a result, PAD remains underdiagnosed and undertreated. PAD is not just a disease of the peripheral arteries, but also an indication of generalized vascular atherosclerosis. PAD patients also have
Kosmas I, Paraskevas, Debabrata, Mukherjee, Thomas F, Whayne   +2 more
openaire   +4 more sources

Peripheral arterial disease

Journal of Wound Care, 1996
An update on the epidemiology, pathology and aetiology of vascular disease
K R, Vowden, P, Vowden
openaire   +2 more sources