Results 131 to 140 of about 1,101,865 (283)

Algorithm for identification of undifferentiated peripheral inflammatory arthritis : a multinational collaboration through the 3e initiative.

, 2011
To develop an algorithm for identification of undifferentiated peripheral inflammatory arthritis (UPIA)
Serra-Bonett, N., Xavier, Ricardo M, Hazlewood, G., Leeb, B.F., Xavier, R.M., W. Vercoutere, V. P. Bykerk, Xavier, Ricardo M., Landewe, R.B.M., Edwards, C.J., D. M. van, P. MARTINEZ-OSUNA, van der Heijde, Desiree M., D. Aletaha, Heijde, D.M. van der, Bykerk, Vivian P, Landewe, Robert B. M., Carmona, Loreto, R. M. Xavier, R. B. M., Aletaha, Daniel, Montecucco, C., Carmona, L., G. Hazlewood, M. Ostergaard, N. Serra Bonett, Leeb, Burkhard F., Hazlewood, Glen, A. I. Catrina, Mjaavatten, Maria D, Bombardier, C., R. B. M. LANDEWE, H. Canhao, Zochling, J., C. Bombardier, B. F. Leeb, J. W. J., Østergaard, Mikkel, Ostergaard, M., Durez, Patrick, Thevissen, Kristof, Leeb, Burkhard F, P. Martinez Osuna, Martinez-Osuna, P., Machado, Pedro, Ostergaard, Mikkel, C. MONTECUCCO, L. Carmona, Aletaha, D., Mjaavatten, Maria D., D. M. van der HEIJDE, Catrina, A.I., Catrina, Anca I., P. Durez, J. Zochling, Bykerk, Vivian P., Thevissen, K., Vercoutere, W., Edwards, Christopher J, K. Thevissen, Edwards, Christopher J., Montecucco, Carlomaurizio, Landewé, Robert B M, Bykerk, V.P., Martinez-Osuna, Pindaro, N. SERRA-BONETT, Machado, P., Canhao, H., J. W. J. BIJLSMA, Bombardier, Claire, Vercoutere, Ward, Durez, P., van der Heijde, Désirée M, Bijlsma, J.W.J., Mjaavatten, M.D., Serra-Bonett, Natali, M. D. Mjaavatten, Canhão, Helena, Catrina, Anca I, Bijlsma, Johannes W J, C. J. Edwards, Zochling, Jane, P. Machado, Hazlewood, G, Bykerk, VP, Canhao, H, van, der Heijde DM, Durez, P, Aletaha, D, Carmona, L, Bijlsma, JWJ, Landewe, RBM, Catrina, AI   +92 more
core   +1 more source

Spatiotemporally Precise Rheumatoid Arthritis Therapy via a Triple‐Locked Cascaded Nanoplatform With Dual‐Channel Self‐Reporting

Advanced Science, EarlyView.
An orthogonally programmable nanotheranostic (MB@YW NPs) enables precision therapy for rheumatoid arthritis. A triple‐locked (pH, HOCl/ONOO−, light) independently drives the release of methotrexate and sulfasalazine. Trackable by dual‐channel fluorescence, this coordinated drug delivery remodels the inflammatory microenvironment to markedly suppress ...
Jihong Liu, Wendi Zhu, Shiyun Xu, Shichang Liu, Wenjun Tang, Xiaoyu Ma, Ting Yang, Haojian Yang, Hongtong Wang, Lu Cao, Lijie Tan, Qi Wang   +11 more
wiley   +1 more source

Perforin deficiency attenuates collagen-induced arthritis

, 2005
Collagen-induced arthritis ( CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8(+) T cells are a major subset controlling the pathogenesis of CIA.
Bauer, K, Mix, E, Thiesen, HJ, Nizze, H, Koczan, D, Kreutzer, HJ, Knipper, A, Holmdahl, Rikard, Ibrahim, SM, Tu-Rapp, H, Lund University., Holmdahl, Rikard,   +11 more
core   +1 more source

Mental disorders in patients with psoriatic arthritis

Научно-практическая ревматология
Psoriatic arthritis is a chronic, progressive, heterogeneous disease that includes peripheral arthritis and spondyloarthritis, associated with cutaneous psoriasis and affecting various body systems. In addition to its impact on physical health, psoriatic
A. B. Borisova, D. Yu. Veltishchev, T. V. Korotaeva, P. O. Tremaskina, L. D. Vorobyova, E. L. Nasonov   +5 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Exome Sequencing Uncovers Phenotypic and Genotypic Heterogeneity in 196 Indian Families Evaluated for Autoinflammatory Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autoinflammatory disorders (AIDs) are a clinically heterogeneous group of inborn errors of immunity primarily caused by dysregulation in the innate immune system. Clinical diagnosis is often challenging due to clinical heterogeneity and the overlapping phenotypes with other inborn errors of immunity and monogenic conditions that mimic AIDs ...
Vaishnavi Ashok Badiger, Periyasamy Radhakrishnan, Suma Balan, Anand P. Rao, Prajna Udupa, Karthik Vijay Nair, Bhagesh Hunakunti, Adarsh Pooradan Prasannakumar, Sanket Limaye, Huzail Gani Shaikh, Rohit Naik, Mahesh Janarthanan, Sudharshan Sridharan, Vishal Sondhi, Sheela Nampoothiri, Hitesh Shah, Sabrinath Mahadevan, Mahabaleshwar Mamadapur, Devang Pandya, Katta Mohan Girisha, Abhay Shivpuri, Amita Moirangthem, Jyothi Raghuram, Gandham Sri Lakshmi Bhavani, Sachin Jeevanagi, Girish Subramaniam, Amita Aggarwal, Anju Shukla, Dhanya Lakshmi Narayanan   +28 more
wiley   +1 more source

Integrating Genetic Modifier Genotype With Serum Proteomics in Duchenne Muscular Dystrophy Clinical Trials Links LTBP4 Genetic Modifier to IL‐23/CD93 Pathways in Muscle

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genetic modifiers of Duchenne muscular dystrophy (DMD) that alter disease severity or response to therapy have been reported using natural history or registry data sets of older corticosteroid‐treated patients. We tested associations of genetic modifiers on motor function outcomes in young (4 to < 7 years) steroid naïve clinical trial ...
Utkarsh J. Dang, Yuan Fang, Daniele Sabbatini, Elena Pegoraro, Luca Bello, Paula R. Clemens, Michela Guglieri, John van den Anker, Jesse Damsker, Laura Hagerty, Yetrib Hathout, Michael Ziemba, Lauren Morgenroth, Surajit Bhattacharya, Kanneboyina Nagaraju, Jyoti K. Jaiswal, Eric P. Hoffman   +16 more
wiley   +1 more source

Animal models of anemia of inflammation: Methodological advances, limitations, and translational applications

Animal Models and Experimental Medicine, EarlyView.
Anemia of inflammation is a highly prevalent secondary anemia complicating chronic inflammatory diseases. Current animal models are categorized into sterile inflammation, disease‐specific, and genetically engineered models, with comparative analysis of their modeling principles, characteristic phenotypes, and translational advantages to elucidate core ...
Jiayi Cheng, Xiaodi Zhou, Qian Liu, Zixian Liu, Hao Wu   +4 more
wiley   +1 more source

Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain

Annals of Neurology, EarlyView.
Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola, Maija Saraste, Edoardo Pedrini, Joel Tuomaala, Luzia Buchholz, Markus Matilainen, Johanna Lindenberg, Eeva‐Christine Brockmann, Maria Sofia Martire, Sofia Sandgren, David Leppert, Jens Kuhle, Tanja Kuhlmann, Martina Absinta, Laura Airas   +14 more
wiley   +1 more source

[Peripheral arthritis in family practice].

Tijdschrift voor gerontologie en geriatrie, 1996
Osteoarthritis is a common disease of the cartilage in a joint for which the general practitioner (GP) is frequently consulted. In this contribution the current policy of GPs is described with respect to patients with peripheral osteoarthritis. For this purpose, the medical records of 196 patients from 14 Dutch general practitioners were studied with ...
openaire   +1 more source