Results 71 to 80 of about 170,793 (256)

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

HLA-B27-Positive Leprosy Masquerading as Peripheral Spondyloarthritis: A Case Report

Case Reports in Dermatology
Introduction: Leprosy, caused by Mycobacterium leprae, is primarily characterized by cutaneous and peripheral nerve involvement. Nonetheless, musculoskeletal manifestations are also frequently observed and are commonly misdiagnosed as ...
Qian Peng, Afang Xu, Qijing Xiao, Xiaobing Wang   +3 more
doaj   +1 more source

Enhanced neurogenesis in the hippocampal dentate gyrus during antigen-induced arthritis in adult rat--a crucial role of immunization.

PLoS ONE, 2014
Neurogenesis in the subgranular zone of the mammalian hippocampal dentate gyrus contributes significantly to brain neuroplasticity. There is evidence that inflammation of the central nervous system inhibits neurogenesis but peripheral inflammation such ...
Johannes Leuchtweis, Michael K Boettger, Fanny Niv, Christoph Redecker, Hans-Georg Schaible   +4 more
doaj   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Measurement properties of instruments assessing peripheral arthritis disease activity in spondyloarthritis: a systematic literature review

RMD Open
Objectives The Assessment of SpondyloArthritis International Society-Spondyloarthritis and Peripheral Arthritis Disease Activity Instrument Selection and Evaluation (ASAS-SPARADISE) project aims to identify instruments to assess disease activity due to ...
Sofia Ramiro, Robert Landewé, Désirée van der Heijde, Anna Molto, Louise Falzon, Clementina López-Medina, Philip Mease, Augusta Ortolan, Dafne Capelusnik, Casper Weber   +9 more
doaj   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Peripheral Neuropathy in Rheumatoid Arthritis [PDF]

BMJ, 1965
C A, PALLIS, J T, SCOTT
openaire   +2 more sources

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Imaging of juvenile spondyloarthritis. Part I: Classifications and radiographs

Journal of Ultrasonography, 2017
Juvenile spondyloarthropathies are manifested mainly by symptoms of peripheral arthritis and enthesitis. By contrast with adults, children rarely present with sacroiliitis and spondylitis.
Iwona Sudoł-Szopińska, Piotr Gietka, Michał Znajdek, Genowefa Matuszewska, Magdalena Bogucevska, Ljubinka Damjanovska-Krstikj, Slavcho Ivanoski   +6 more
doaj   +1 more source

Microfluidic Valve‐Integrated Garment for Smooth Sequential Gradient Mechanotherapy

Advanced Intelligent Systems, EarlyView.
We present a soft wearable sleeve that delivers smooth, gap‐free compression using overlapping air‐filled actuators and tiny microfluidic valves. The system reduces bulk, lowers power needs, and uses a smartphone‐sized control box. It can provide sequential gradient compression, gradient pressure holding, and fast deflation, supporting more portable ...
Run Ze Gao, Chen Xi Huang, Drew M. Werbowski, Jacqueline Mary Kormylo, Clark R. Dickerson, Carolyn L. Ren   +5 more
wiley   +1 more source