KLF7-transfected Schwann cell graft transplantation promotes sciatic nerve regeneration [PDF]
, 2017 Our former study demonstrated that Krüppel-like Factor 7 (KLF7) is a transcription factor that stimulates axonal regeneration after peripheral nerve injury.
Cheng, Yong-xia +9 more
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Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury. [PDF]
, 2018 BACKGROUND:In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9 performs essential functions in the acute response to injury. Whether MMP-9 activity contributes to late-phase injury or whether MMP-9 expression or activity after ...
Angert, Mila +6 more
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Beta secretase activity in peripheral nerve regeneration
Neural Regeneration Research, 2017 While the peripheral nervous system has the capacity to regenerate following a nerve injury, it is often at a slow rate and results in unsatisfactory recovery, leaving patients with reduced function.
Carolyn Tallon, Mohamed H Farah
doaj +1 more source
Autophagy-targeting modulation to promote peripheral nerve regeneration
Neural Regeneration ResearchNerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.
Yan Chen, Hongxia Deng, Nannan Zhang
doaj +1 more source
Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. [PDF]
PLoS Genetics, 2019 Following injury, axons of the peripheral nervous system have retained the capacity for regeneration. While it is well established that injury signals require molecular motors for their transport from the injury site to the nucleus, whether kinesin and ...
Melissa Ducommun Priest +3 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 Peripheral nerve injury (PNI) is a structural event with harmful consequences worldwide. Due to the limited intrinsic regenerative capacity of the peripheral nerve in adults, neural restoration after PNI is difficult.
Yongke Yang +11 more
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Journal of Investigative Surgery, 2021 Introduction We investigated the possible beneficial effect of dimethylsulfoxide (DMSO) on peripheral nerve repair in rats. Methods: Seventy rats were divided into four groups: control, sham, DMSO-L, and DMSO-IP. Except in the control group, nerve repair
Elif Sanli +2 more
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Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. [PDF]
, 2019 BackgroundNeurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are involved in vascular remodeling; however,
Hsueh, Yuan-Yu +4 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The role of exercise on peripheral nerve regeneration: from animal model to clinical application
Heliyon, 2021 Peripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may lead to sensory and motor functions deficits and even lifelong disability, causing important ...
Grazia Maugeri +7 more
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