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Peripheral Nervous System (PNS) Myelin Diseases

Cold Spring Harbor Perspectives in Biology
This is a review of inherited and acquired causes of human demyelinating neuropathies and a subset of disorders that affect axon-Schwann cell interactions. Nearly all inherited demyelinating neuropathies are caused by mutations in genes that are expressed by myelinating Schwann cells, affecting diverse functions in a cell-autonomous manner.
Steven S, Scherer, John, Svaren
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Lyme disease and the peripheral nervous system

Muscle & Nerve, 2003
AbstractLyme disease, the multisystem infectious disease caused by the tick‐borne spirochete Borrelia burgdorferi, causes a broad variety of peripheral nerve disorders, including single or multiple cranial neuropathies, painful radiculopathies, and diffuse polyneuropathies. Virtually all appear to be varying manifestations of a mononeuropathy multiplex.
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Central and Peripheral Nervous System Diseases

2007
Immune diseases of the central and peripheral nervous system constitute an heterogeneous group of disorders which share a significative implication of the immune system in pathophysiology. Multiple sclerosis (MS), Guillain Barre syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are considered of autoimmune origin, with an ...
Dorothée Chabas   +2 more
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Diseases of the Peripheral Nervous System

1999
The oral cavity and the surrounding facial tissue maybe part of the clinical spectrum of different neurological conditions. Most of these disorders involve the 7th, facial, and the 12th, hypoglossal, cranial nerves.
L. Bianchi, M. Argenta, G. Nini
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Peripheral nervous system disease in Systemic Lupus Erythematosus

2019
Objectives: In a multi-ethnic/racial, prospective SLE inception cohort, to determine the frequency, clinical characteristics, associations and outcomes in different types of peripheral nervous system (PNS) disease. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including seven types of PNS disease.
Hanly, John   +5 more
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Early peripheral nervous system manifestations of infantile Krabbe disease

Pediatric Neurology, 2003
Early infantile Krabbe disease is relatively frequent in the Muslim-Arab population in Israel. It can be easily diagnosed when it presents with the classic clinical picture characterized by central nervous system manifestations of spasticity, irritability, motor regression and seizures associated with a positive family history.
Isabelle, Korn-Lubetzki   +5 more
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Peripheral Nervous System Damage in Experimental Chronic Chagas' Disease

The American Journal of Tropical Medicine and Hygiene, 1987
Electromyographic and histopathologic studies were performed in Rockland mice chronically infected with CA-I Trypanosoma cruzi strain. At 4 months post-infection the emg failed to show spontaneous activity, but a diminished interference pattern was detected in half of the infected group, while mean motor unit potential amplitude and duration were ...
S M, González Cappa   +6 more
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Involvement of peripheral nervous system in juvenile Parkinson's disease

Acta Neurologica Scandinavica, 2009
We evaluated, by using electrophysiological techniques, 29 patients with juvenile Parkinson's disease (JP), who had no known causes or clinical signs of neuropathy. Electromyographic evidence of chronic partial denervation with reinnervation was observed in nine patients (34.6%).
A B, Taly, U B, Muthane
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T lymphocyte autoimmunity in peripheral nervous system autoimmune disease

Agents and Actions, 1986
Autoaggressive T cells specific for the PNS myelin P2 protein play a central role in the initiation of EAN in the Lewis rat, although there is as yet no direct experimental evidence that the T cells can themselves mediate demyelination in vivo. However, the striking similarities in the pathogenesis of EAN and the Guillain-Barre syndrome suggest that T ...
C, Linington, H, Wekerle, R, Meyermann
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Diseases of the peripheral nervous system

2000
Abstract Magnetic stimulation has found a number of applications in the investigation of diseases where the predominant abnormality is in peripheral nerves. The use of stimulation over the cervical and lumbar enlargements to excite motor roots at the exit foramina has been tried in the search for a technique to detect proximal conduction
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