Results 91 to 100 of about 840,120 (301)

Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions [PDF]

, 2019
No abstract ...
Berry, C, Ford, TJ, Hainsworth, AH, Kaski, JC, Pereira, AC, Sidik, N, Touyz, RM   +6 more
core   +2 more sources

Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy

Advanced Functional Materials, EarlyView.
Many cancer nanotherapeutics, while potent, suffer from the inability to escape from the tumor vasculature, especially in the absence of endothelial permeability. In this work, ultrasmall gold nanoclusters could engineer nanomaterials induced endothelial leakiness (NanoEL) and harness strong NIR induced photothermal characteristics to suppress tumor ...
Nengyi Ni, Kuoran Xing, Bihan Zhang, Baoteng Wang, Yinglu Chen, Jianping Xie, Xiao Sun, Jinping Wang, David Tai Leong   +8 more
wiley   +1 more source

Immune Checkpoint Inhibitor-Associated Myocarditis

JACC: Case Reports, 2020
Immune checkpoint inhibitors (ICIs) can induce immunity-related adverse events. We demonstrate the clinical use of cardiac magnetic resonance and endomyocardial biopsy in the diagnosis and subsequent monitoring of ICI-associated myocarditis, suggesting ...
Grigorios Chatzantonis, MD, Georg Evers, MD, Claudia Meier, MD, Michael Bietenbeck, PhD, Anca Florian, MD, Karin Klingel, MD, Annalen Bleckmann, MD, Ali Yilmaz, MD   +7 more
doaj   +1 more source

Longitudinal Relationships of Subclinical Cardiovascular Disease with Physical Function in Older Adults [PDF]

, 2009
Low ankle-arm index (AAI), a marker of peripheral arterial disease, predicts incident disability in older adults. Elevated pulse wave velocity (PWV), a measure of arterial stiffness, increases risk of cardiovascular events and mortality.
Watson, Nora Lynn
core  

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

A Systematic Review Examining the Association of Falls With Diabetes‐Related Foot Ulcers

Journal of Foot and Ankle Research
Background The aim of this study was to systematically review the risk of falls in people with diabetes‐related foot ulcers (DFU). Methods A systematic search of Medline, Pubmed, Embase, Cochrane and CINAHL was undertaken to identify observational ...
Mike Wu, Mallika Sinha, Chanika Alahakoon, Kristen S. Barratt, Shivshankar Thanigaimani, Jonathan Golledge   +5 more
doaj   +1 more source

How to Undertake a Clinically Relevant Systematic Review in a Rapidly Evolving Field: Magnetic Resonance Angiography [PDF]

, 2002
Objectives: The aim was to determine which generations of the evolving technology of magnetic resonance angiography (MRA) are currently of clinical relevance in two clinical applications. Our purpose was to plan a systematic review that would be valuable
Airey, C.M., Bamford, J.M., Berry, E., Cullingworth, J., Davies, L.M., Gough, M.J., Kelly, S., Meaney, J.F.M., Smith, M.A., Westwood, M.E.   +9 more
core  

The impact of peripheral arterial disease on patients with mechanical circulatory support. [PDF]

, 2020
Background: Left ventricular assist devices (LVAD) are indicated as bridging or destination therapy for patients with advanced (Stage D) heart failure and reduced ejection fraction (HFrEF). Due to the clustering of the mutual risk factors, HFrEF patients
Ajmal, Rasikh, Al-Khadra, Yasser, Alraies, M Chadi, Asfour, Abedelrahim, Darmoch, Fahed, Gardi, Delair, Glazier, James, Mir, Tanveer, Moussa-Pacha, Homam, Sattar, Yasar, Ullah, Waqas   +10 more
core   +1 more source

Hemodynamic profiles of functional and dysfunctional forms of repetitive thinking [PDF]

, 2016
Background: The ability of the human brain to escape the here and now (mind wandering) can take functional (problem solving) and dysfunctional (perseverative cognition) routes.
Brosschot, Jos F., Lonigro, Antonia, Medea, Barbara, Ottaviani, Cristina, Thayer, Julian F., van Diest, Ilse   +5 more
core   +2 more sources

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source