Results 41 to 50 of about 840,120 (301)

Clinical medical decision-making of acute aortic intramural hematoma: A non-randomized retrospective case study

Journal of Interventional Medicine, 2020
Objective: This study explored the timing of interventional treatment for acute intramural aortic hematoma (IMH) and the corresponding high-risk factors for its development into local aortic dissection (AD).
Hao Qin, Li Wei, Bo Zhang, Yujing Wang, Yamin Liu   +4 more
doaj   +1 more source

Systematic Review and Meta‐Analysis of Peak Wall Stress and Peak Wall Rupture Index in Ruptured and Asymptomatic Intact Abdominal Aortic Aneurysms

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Prior studies have suggested aortic peak wall stress (PWS) and peak wall rupture index (PWRI) can estimate the rupture risk of an abdominal aortic aneurysm (AAA), but whether these measurements have independent predictive ability over ...
Tejas P. Singh, Joseph V. Moxon, T. Christian Gasser, Jonathan Golledge   +3 more
doaj   +1 more source

Animal models of ischemic limb ulcers: a systematic review and meta-analysis

BMJ Open Diabetes Research & Care, 2020
The aims of this systematic review were to assess the clinical relevance and quality of previously published animal models of ischemic ulceration and examine the available evidence for interventions improving ulcer healing in these models.
James Phie, Jonathan Golledge, Shivshankar Thanigaimani   +2 more
doaj   +1 more source

Potential of Disease-Modifying Anti-Rheumatic Drugs to Limit Abdominal Aortic Aneurysm Growth

Biomedicines, 2022
Inflammation is strongly implicated in the pathogenesis of abdominal aortic aneurysms (AAA). This review examined the potential role of biologic disease-modifying anti-rheumatic drugs (bDMARDs) as repurposed drugs for treating AAA.
Shivshankar Thanigaimani, Muhammad Ibrahim, Jonathan Golledge   +2 more
doaj   +1 more source

Major Limb Amputations: A Tertiary Hospital Experience in Northwestern Tanzania. [PDF]

, 2012
Major limb amputation is reported to be a major but preventable public health problem that is associated with profound economic, social and psychological effects on the patient and family especially in developing countries where the prosthetic services ...
Chalya, Phillipo L, Chandika, Alphonce B, Dass, Ramesh M, Gilyoma, Japhet M, Mabula, Joseph B, Mbelenge, Nkinda, Ngayomela, Isdori H   +6 more
core   +3 more sources

The molecular mechanisms of mitochondrial dynamics and mitophagy and their complex association with cancer drug resistance

Journal of Translational Medicine
The development of drug resistance by cancer cells is among the main reasons for cancer treatment failure, greatly limiting the efficacy of chemotherapy, targeted therapy, and immunotherapy.
Zhuo Zhao, Yuru Ren, Meijie Yuan, Guobin Liu, Jian Sun   +4 more
doaj   +1 more source

Association of Oral Anticoagulation Prescription with Clinical Events in Patients with an Asymptomatic Unrepaired Abdominal Aortic Aneurysm

Biomedicines, 2022
Background: Most abdominal aortic aneurysms (AAA) have large volumes of intraluminal thrombus which has been implicated in promoting the risk of major adverse events.
Jonathan Golledge, Jason Jenkins, Michael Bourke, Bernard Bourke, Tejas P. Singh   +4 more
doaj   +1 more source

Silence of the limbs: pharmacological symptomatic treatment of intermittent claudication [PDF]

, 2010
Several oral "vasoactive" drugs claim to increase walking capacity in patients with intermittent claudication (IC). Naftidrofuryl, cilostazol, buflomedil, and pentoxifylline are the most studied molecules.
De Backer, Gui, De Backer, Tine, De Buyzere, Marc, Van Bortel, Lucas, Vander Stichele, Robert   +4 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Protocol for the induction of innate immune memory in human smooth muscle cells and endothelial cells in vitro

STAR Protocols
Summary: Non-immune cells, like innate immune cells, can develop a memory-like phenotype in response to priming with microbial compounds or certain metabolites, which enables an enhanced response to a secondary unspecific stimulus. This paper describes a
Jannik Sonnenberg, Dennis Schwarz, Sina MM. Lagache, Lucia Schnack, Helena Körner, Merle Leffers, Hannah Hardege, Yuanyuan Liu, Holger Reinecke, Hannes M. Findeisen, Yahya Sohrabi   +10 more
doaj   +1 more source