Results 111 to 120 of about 582,261 (305)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A Simplified Approach to Analyzing Multi-regional Core-Periphery Models [PDF]

This paper shows that the evolutionary process of spatial agglomeration in multi-regional core-periphery models can be explained analytically by a much simpler method than the continuous space approach of Krugman (1996). The proposed method overcomes the
Akamatsu, Takashi, Takayama, Yuki
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Climate Change Adaptation:A Report on Climate Change Adaptation Measures for Low Volume Roads in the Northern Periphery [PDF]

, 2012
The European Union ROADEX Project 1998 – 2012 was a trans-national roads co-operation aimed at developing ways for interactive and innovative management of low traffic volume roads throughout the cold climate regions of the Northern Periphery Area of ...
Hudecz, Adriána
core  

Periphery versus periphery: The stakes of separatist war

, 2014
This is replication data for main and supplementary tables in Periphery versus Periphery: The Stakes of Separatist War, Bethany Lacina, JOP. The data are ethnic group-year observations, based on the Ethnic Power Relations Dataset (http://thedata.harvard ...
Lacina, Bethany
core   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Cinema at the Periphery

, 2010
Cinema at the Periphery examines the periphery in terms of locations, practices, methods, and themes. It includes geographic case studies of small national cinemas located at the global margins, like New Zealand and Scotland, but also of filmmaking that ...

core   +3 more sources

The Global Pleasure Periphery 35 Years Later: Evolving Regional Contours

, 2011
In 1975 Turner and Ash famously described the emergence of the 'pleasure periphery' in the Caribbean, Mediterranean and South Pacific as a manifestation of the worldwide diffusion of mass tourism. Although frequently cited, few studies have subsequently
Shakeela, Aishath, Castley, Guy, Weaver, David   +2 more
core  

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source