Results 111 to 120 of about 1,006,221 (298)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
An entrepreneurial countryside?
Cidades, Comunidades e Território, 2021 Architecture and urban design are central selling points in globalized models of urban development, advocated by city strategies to boost competitiveness.
Heini-Emilia Saari
doaj
Analyzing urban sprawl and urbanisation dynamics: A case study of Bejaia, Oued-Ghir, and Tala-Hamza [PDF]
Glasnik Srpskog Geografskog DruštvaUnderstanding urban sprawl is crucial as it provides a dynamic perspective on urban areas, revealing the driving forces and explanatory factors behind their expansion.
Tebbane Bouktit Kaouther +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
MODERN GEODEMOGRAPHIC SITUATION IN PERIPHERAL RURAL AREAS IN THE SOUTH OF EUROPEAN RUSSIA
Наука. Инновации. Технологии, 2022 The demographic situation in Russia, despite the measures taken, largely retains negative. Low fertility combined with high mortality led to the depopulation effect resulting in natural population decline in many regions of the country, which can not ...
Natalia Aleksandrovna Shchitova +1 more
doaj
A Center-Periphery Model of Monetary Coordination and Exchange Rate Crises [PDF]
The paper analyzes the modalities and consequences of a breakdown of cooperation between the monetary authorities of inflation-prone Periphery Countries that use an exchange rate peg as an anti- inflationary device, when the Center is hit by an aggregate
Giancarlo Corsetti +2 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Centre-periphery tensions regarding Central and Eastern Europe [PDF]
, 2012 Security issues have played an important role in widening the European Union with eight Central and Eastern European economies. The time since have proved these concerns to be correct.
Blahó, András
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Utopian semiospheres: Isolation and dialogue across borders
Sign Systems StudiesThe paper applies Juri Lotman’s theory of the semiosphere to utopian studies with the aim of identifying the principal components and mode of functioning of classic utopian discourse.
Artur Blaim, Ludmiła Gruszewska-Blaim
doaj +1 more source