Results 141 to 150 of about 1,205,038 (394)
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
MODERN GEODEMOGRAPHIC SITUATION IN PERIPHERAL RURAL AREAS IN THE SOUTH OF EUROPEAN RUSSIA
Наука. Инновации. Технологии, 2022 The demographic situation in Russia, despite the measures taken, largely retains negative. Low fertility combined with high mortality led to the depopulation effect resulting in natural population decline in many regions of the country, which can not ...
Natalia Aleksandrovna Shchitova +1 more
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Monetary Policy and Regional Interest Rates in the United States, 1880-2002 [PDF]
The long running debate among economic historians over how long it took regional financial markets in the United States to become fully integrated should be of considerable interest to students of monetary unions. This paper reviews the debate, discusses
Hugh Rockoff, John Landon-Lane
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Universitas Humanística, 2008 Lately, several authors have been analyzing the changes in rural areas triggered by globalization. The concepts of new rurality and pluriactivity have allowed progress along these lines, highlighting the new difficulties facing the most vulnerable ...
Laura María Torres
doaj
Velocity accelerator for particles [PDF]
, 1972 Sheet explosive and metal tube, fitted to the inner periphery of a cam-shaped chamber, accelerate particles to velocities nearing 20 km/sec to evaluate efficacy of spacecraft meteoroid ...
Wilson, A. H.
core +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source