Results 161 to 170 of about 1,205,038 (394)
Vægi atkvæða og pólitískt jafnrétti
In this article an attempt is made to clarify the concept of political equality and how it relates to democratic government. The authors relate that with the general discussion on constitutional change in Iceland.
Grétar Þór Eyþórsson +1 more
doaj
Planning Guidelines for the Development of Urban Periphery - Case of Akola
Radhika R. Raut +2 more
openalex +1 more source
BCI learning induces core-periphery reorganization in M/EEG multiplex\n brain networks [PDF]
Marie‐Constance Corsi +8 more
openalex +1 more source
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Lysosome lipid signalling from the periphery to neurons regulates longevity [PDF]
Marzia Savini +17 more
openalex +1 more source
The role of lipid metabolism in neuronal senescence
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source

