Results 81 to 90 of about 16,240 (199)

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Drug reaction with eosinophilia and systemic symptoms syndrome after total knee arthroplasty infection and placement of antibiotic spacer

Arthroplasty Today, 2019
Though 2-stage revision is considered the gold standard in North America for treatment of periprosthetic joint infection, complications can be associated with use of antibiotic-impregnated spacers.
Katharine D. Harper, MD, Stephen J. Incavo, MD   +1 more
doaj   +1 more source

Creating Perforations in the Sclerotic Region of the Proximal Tibia During Total Knee Arthroplasty to Enhance Prosthesis Stability

Orthopaedic Surgery, Volume 17, Issue 5, Page 1397-1405, May 2025.
Abnormal stress in the proximal tibia modifies the bone mineral density distribution pattern, and drilling in the sclerotic region during total knee arthroplasty is correlated with enhanced prosthesis stability. ABSTRACT Objective In patients with varus deformity of the knee, the redistribution of the subchondral bone mineral density (BMD) of the tibia
Chao Sun, Chunyan Wang, Jintang Li, Chengyan Liu, Zhilin Wei, Zhiguo Bi, Yeran Li, Shuqiang Li   +7 more
wiley   +1 more source

Customized Metal 3D Printed Total Wrist Prosthesis in the Treatment of Severely Destroyed Wrist: Design Rationale and Clinical Applications

Orthopaedic Surgery, Volume 17, Issue 5, Page 1536-1546, May 2025.
Four patients with severe wrist destruction from various causes were treated with customized 3D‐printed prostheses. In addition to the specific articular surface matching their original radiocarpal joint, two innovative proximal component designs were created to address different bone defects.
Qipei Wei, Chang Liu, Shanlin Chen, Min Liu   +3 more
wiley   +1 more source

Retrospective Analysis of Pseudotumor of the Hip: Clinical Management and Outcomes

Orthopaedic Surgery, EarlyView.
The surgical revision treatment of patients affected by pseudotumor guarantees a good functional result with a low risk of failure of the new implant. However, pseudotumor requires a systematic and efficient surgical approach to be quickly and successfully resolved.
Roberta Laranga, Luca Cevolani, Eric Lodewijk Staals, Anna Mammone, Laura Campanacci, Barbara Dozza, Davide Maria Donati, Giuseppe Bianchi   +7 more
wiley   +1 more source

Risk Factors for Recurrence of Periprosthetic Joint Infection in Patients with Hemophilia

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Relevance. Joint arthroplasty is a surgical method for treating deforming osteoarthritis, the use of which is increasing annually. With improved access to replacement therapy for patients with hemophilia, arthroplasty has become an effective treatment ...
A. Yu. Kim, V. A. Surimova, V. Yu. Zorenko, G. A. Klyasova, S. M. Kulikov   +4 more
doaj   +1 more source

A Novel 3D‐Printed Strut‐Type Prosthesis Reconstructs the Hemicortical Defect After Distal Femur Parosteal Osteosarcoma Resection: The Mid‐Term Follow‐Up Outcome

Orthopaedic Surgery, EarlyView.
This study developed a novel three‐dimensional (3D)‐printed strut‐type prosthesis for reconstruction of bone defects following hemicortical resection of distal femoral parosteal osteosarcoma. The mid‐term follow‐up results demonstrated that this prosthesis effectively restored limb function and exhibited favorable bone ingrowth and osseointegration ...
Jianhua Mu, Yitian Wang, Han Liu, Xuanhong He, Zhuangzhuang Li, Minxun Lu, Fan Tang, Yi Luo, Yong Zhou, Li Min, Chongqi Tu   +10 more
wiley   +1 more source

The Effect of the Coronal Alignment of Extension Stem on Component Displacement and Stress During Total Knee Arthroplasty: A Finite Element Study

Orthopaedic Surgery, EarlyView.
Kinematic alignment (KA) increases prosthesis displacement and reduces stress shielding in total knee arthroplasty (TKA), while short extension stems reduce prosthesis displacement but increase stress shielding, and their combination may have complementary effects. This requires further research to confirm.
Lingce Kong, Xingkai Wang, Huijun Kang, Zhenhui Huo, Ming Li, Fei Wang, Wei Lin   +6 more
wiley   +1 more source

Evaluating the Impact of Patellar Resurfacing in Medial Stabilized Total Knee Arthroplasty: A Retrospective Cohort Study

Orthopaedic Surgery, EarlyView.
In medial‐stabilized total knee arthroplasty with a single implant design, patellar resurfacing did not improve pain or patient‐reported outcomes and slightly increased operative time, while non‐resurfaced knees showed marginally better range of motion and function, supporting an individualized, non‐inferior approach to patellar management.
Isaac Sontag‐Milobsky, Giancarlo Riccobono, T. Jacob Selph Jr, Kevin D. Hardt, David W. Manning   +4 more
wiley   +1 more source

Optimal intrathecal morphine dosing for revision hip arthroplasty: an observational study

Anaesthesia, EarlyView.
Shalini Patel, Vassia Paschou, Jane Quinlan, Ben Kendrick, Nicolas Suarez   +4 more
wiley   +1 more source