Results 111 to 120 of about 170,406 (307)

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus

Frontiers in Immunology, 2019
Intraperitoneal inoculation with live influenza A virus confers protection against intranasal infections in mice and ferrets. However, the responses of peritoneal cells to influenza A virus have not been investigated.
Avishekh Gautam, Byoung Kwon Park, Te Ha Kim, Madhav Akauliya, Dongbum Kim, Sony Maharjan, Joongwon Park, Jinsoo Kim, Hanseul Lee, Man-Seong Park, Younghee Lee, Hyung-Joo Kwon, Hyung-Joo Kwon   +12 more
doaj   +1 more source

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib. [PDF]

, 2016
Signaling via the B cell receptor (BCR) plays an important role in the pathogenesis and progression of chronic lymphocytic leukemia (CLL). This is underscored by the clinical effectiveness of ibrutinib, an inhibitor of Bruton's tyrosine kinase (BTK) that
Chen, L, Chen, Y, Choi, MY, Cui, B, Kipps, TJ, Rassenti, LZ, Widhopf Ii, GF, Wu, Christina, Yu, J, Zhang, L   +9 more
core   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Significance of Self‐Expandable Metallic Stent for Postoperative Intra‐Abdominal Infection After Pancreatoduodenectomy in Patients With a Hard Pancreas

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Self‐expandable metal stents (SEMS) are often used for preoperative biliary drainage in pancreatoduodenectomy (PD); however, their impact on postoperative intra‐abdominal infection (POAI) remains unclear. This study aimed to evaluate the clinical significance of SEMS in relation to POAI.
Kosuke Mori, Haruyoshi Tanaka, Nana Kimura, Mina Fukasawa, Ayaka Itoh, Yoshihiro Shirai, Kazuto Shibuya, Kentaro Nagaoka, Yoshihiro Yamamoto, Tsutomu Fujii   +9 more
wiley   +1 more source

Independent Prognostic Significance of Perforation in Colorectal Cancer: Insights From a Propensity Score‐Matched Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
Perforated colorectal cancer (PCC) is considered to have a poor prognosis; however, it remains unclear whether this is attributable to perforation itself or to perforation‐related clinicopathological factors. In this study, we analyzed prognosis using propensity score matching with perforation‐related factors and demonstrated that perforation is an ...
Yoshiaki Fujii, Shuhei Ueno, Yoshinaga Aoyama, Hiroyuki Imafuji, Takahisa Hirokawa, Hirotaka Miyai, Masahiro Kimura, Kenji Kobayashi, Shuji Takiguchi   +8 more
wiley   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Mid‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter retrospective cohort study compared mid‐term oncological outcomes between intracorporeal anastomosis (IA) and extracorporeal anastomosis (EA) in minimally invasive colectomy for colon cancer using propensity score–matched data from 2018 to 2022.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Shinya Hamasu, Keita Hanada, Kenji Kawada, Teppei Murakami, Satoshi Nagayama, Kazutaka Obama   +9 more
wiley   +1 more source

peritoneal cavity

Citation: 'peritoneal cavity' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11081 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

LiveAscaris lumbricoidesin the peritoneal cavity [PDF]

Annals of Saudi Medicine, 2007
Infestation with Ascaris lumbricoides is a worldwide phenomenon with up to a quarter of the world population, mostly in the third-world countries, infected.1,2 A. lumbricoides resides mostly in the middle third of the jejunum, but perforations attributed to this parasite have been described mostly in the terminal ileum, cecum, Meckel’s diverticulum and
openaire   +3 more sources

Short‐Term Outcomes of Robot‐Assisted Versus Laparoscopic Colectomy for Colon Cancer: A Propensity Score‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
This study compared short‐term outcomes of robot‐assisted versus laparoscopic colectomy for colon cancer using 1:1 propensity score matching. Among 218 matched pairs, robot‐assisted colectomy was associated with reduced blood loss, fewer conversions to open surgery, lower overall complication rates, and shorter hospital stays, despite longer operative ...
Akira Inoue, Yujiro Nishizawa, Yoshinori Kagawa, Masahiro Hashimoto, Shinya Kato, Yoshihiro Morimoto, Taishi Hata, Makoto Fujii, Masaaki Motoori, Kazumasa Fujitani   +9 more
wiley   +1 more source