Results 31 to 40 of about 255,080 (253)

Effect of high glucose concentration on the synthesis of monocyte chemoattractant protein-1 in human peritoneal mesothelial cells: Involvement of protein kinase C [PDF]

, 2001
Human peritoneal mesothelial cells (HMC) contribute to the activation and control of inflammatory processes in the peritoneum by their potential to produce various inflammatory mediators.
Lederer, Stephan R., Sitter, Thomas, Sellmayer, Alois, Mandl-Weber, Sonja, Haslinger, Bettina, Alois Sellmayer, Bettina Haslinger, Sonja Mandl-Weber, Thomas Sitter, Stephan R. Lederer   +9 more
core   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Physical activity and exercise in peritoneal dialysis: International Society for Peritoneal Dialysis and the Global Renal Exercise Network practice recommendations

, 2022
Life participation requiring physical activity and physical function is a key patient-reported outcome for people receiving peritoneal dialysis (PD). Clinician guidance is required from multidisciplinary sources regarding exercise and activity advice to ...
Tarca, B., Thompson, S., Harasemiw, O., Bohm, C., Bennett, P.N., Brown, L.   +5 more
core   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Circulating Muscle Markers for Sarcopenia in Peritoneal Dialysis

International Journal of Nephrology
Sarcopenia, characterized by the progressive decline in muscle mass and function, is an important complication among patients undergoing peritoneal dialysis (PD).
Lixing Xu, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Cheuk-Chun Szeto   +5 more
doaj   +1 more source

Results of application of the ISPD guidelines to the management of peritoneal dialysis in a single center in Sudan

Journal of Infection and Public Health, 2017
Summary: The culture negative peritonitis in Sudan 2010 was 46% exceeding 20% of the recommended ISPD (International Society for Peritoneal Dialysis) guidelines. This study reports an update after applying the standard ISPD protocol.
Sahar M. Kheir, Shamsoun K. Kafi, Patrik Ryden, Haitham Elbir, Mohammed A. Soliman, Shima Ali, Ramy Abulikailik, Khadega Ahamed, Hasan Abu-Aisha   +8 more
doaj   +1 more source

HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome

Cell Death and Disease, 2023
Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial fibrosis is the final stage of almost all progressive CKD. To date, the pathogenesis of renal fibrosis remains unclear, and there is a lack of effective treatments,
Jialin Li, Qisheng Lin, Xinghua Shao, Shu Li, Xuying Zhu, Jingkui Wu, Shan Mou, Leyi Gu, Qin Wang, Minfang Zhang, Kaiqi Zhang, Jiayue Lu, Zhaohui Ni   +12 more
doaj   +1 more source

The Japanese Hernia Society (JHS) Guidelines for Adult Groin Hernia Management 2024

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Groin hernia is a common surgical condition. The Japanese Hernia Society (JHS) Guidelines for Groin Hernia Management 2024 were developed to reflect both international evidence and the realities of clinical practice in Japan. This article is an authorized English translation of a summary of the adult section of the JHS Guidelines for Groin ...
Hitoshi Idani, Gen Shimada, Katsuhito Suwa, Yoshiko Honda, Yuji Konishi, Itsuro Nagae, Kenta Saito, Takafumi Tamura, Satoshi Nagayama, Chie Tanaka, Seiko Hirono   +10 more
wiley   +1 more source

Low-Protein Diet Supplemented with Keto Acids Is Associated with Suppression of Small-Solute Peritoneal Transport Rate in Peritoneal Dialysis Patients

International Journal of Nephrology, 2011
Objective. We investigate whether low-protein diet would show benefits in suppressing peritoneal transport rate in peritoneal dialysis (PD) patients. Methods.
Na Jiang, Jiaqi Qian, Aiwu Lin, Wei Fang, Weiming Zhang, Liou Cao, Qin Wang, Zhaohui Ni, Qiang Yao   +8 more
doaj   +1 more source

Outcomes of Patients With AL Amyloidosis and End‐Stage Renal Disease After Initiation of Therapy

American Journal of Hematology, EarlyView.
ABSTRACT In AL amyloidosis, advanced renal disease can impact treatment options and cause significant morbidity. Patients with ESRD requiring dialysis are a group with currently unmet needs. In this collaborative study, we identified 362 patients from three European centers who initiated dialysis during the course of the disease.
Foteini Theodorakakou, Lilli Sophie Sester, Ute Hegenbart, Paolo Milani, Claudia Bellofiore, Erasmia Psimenou, Charikleia Gakiopoulou, Meletios A. Dimopoulos, Giovanni Palladini, Stefan O. Schönland, Efstathios Kastritis   +10 more
wiley   +1 more source