Results 101 to 110 of about 71,423 (312)

TGF-β1 Promotes Lymphangiogenesis during Peritoneal Fibrosis [PDF]

Journal of the American Society of Nephrology, 2013
Peritoneal fibrosis (PF) causes ultrafiltration failure (UFF) and is a complicating factor in long-term peritoneal dialysis. Lymphatic reabsorption also may contribute to UFF, but little is known about lymphangiogenesis in patients with UFF and peritonitis. We studied the role of the lymphangiogenesis mediator vascular endothelial growth factor-C (VEGF-
Hiroshi, Kinashi, Yasuhiko, Ito, Masashi, Mizuno, Yasuhiro, Suzuki, Takeshi, Terabayashi, Fumiko, Nagura, Ryohei, Hattori, Yoshihisa, Matsukawa, Tomohiro, Mizuno, Yukihiro, Noda, Hayato, Nishimura, Ryosuke, Nishio, Shoichi, Maruyama, Enyu, Imai, Seiichi, Matsuo, Yoshifumi, Takei   +15 more
openaire   +2 more sources

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

The Transfer of the Hepatocyte Growth Factor Gene by Macrophages Ameliorates the Progression of Peritoneal Fibrosis in Mice [PDF]

, 2023
Yoko Obata, Katsushige Abe, Masanobu Miyazaki, Takehiko Koji, Yasuhiko Tabata, Tomoya Nishino   +5 more
openalex   +1 more source

Peritonitis Meconial y Fibrosis Quística Meconium peritonitis and cystic fibrosis

Revista de Ciencias Médicas de Pinar del Río, 2008
La fibrosis quística (FQ) es una enfermedad génetica autosómica recesiva causada por más de 600 mutaciones conocidas del gen que codifica para la proteína de la membrana: Regulador de la membrana F.Q (CFTR). Es una enfermedad que en el período neonatal puede manifestarse por distres respiratorio, colestasis intrahepática e íleo meconial. Presentamos el
Sergio Piloña Ruíz, Omar León Vara Cuesta, Vilma Llabona Chávez, Jesús Juan Rodríguez, Yurisbelkis Pérez Lorenzo   +4 more
openaire   +1 more source

Significance of Self‐Expandable Metallic Stent for Postoperative Intra‐Abdominal Infection After Pancreatoduodenectomy in Patients With a Hard Pancreas

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Self‐expandable metal stents (SEMS) are often used for preoperative biliary drainage in pancreatoduodenectomy (PD); however, their impact on postoperative intra‐abdominal infection (POAI) remains unclear. This study aimed to evaluate the clinical significance of SEMS in relation to POAI.
Kosuke Mori, Haruyoshi Tanaka, Nana Kimura, Mina Fukasawa, Ayaka Itoh, Yoshihiro Shirai, Kazuto Shibuya, Kentaro Nagaoka, Yoshihiro Yamamoto, Tsutomu Fujii   +9 more
wiley   +1 more source

Laparoscopy Pneumoperitoneum Fuzzy Modeling [PDF]

, 2011
: Gas volume to intra-peritoneal pressure fuzzy modeling for evaluating pneumoperitoneum in videolaparoscopic surgery is proposed in this paper. The proposed approach innovates in using fuzzy logic and fuzzy set theory for evaluating the accuracy of the ...
Joao L. M. C. Azevedo, Jose E. Araujo Jr., Otavio M. Becker Jr.   +2 more
core   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]

, 2015
The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R, Beon M, Bryan N, Butterfield TA, Connolly MK, Desmoulière A, Fallowfield JA, Galván‐Peña S, Gordon S, Goumans M, Hu B, Ito T, Jimenez SA, Korns D, Krieg T, Lassen S, Lech M, Leibovich SJ, Lev B, Mantovani A, Mantovani A, Molumdar K, Nestle FO, O’Doherty U, Piera‐Velazquez S, Poland GA, Rafii R, Rigamonte E, Tacke F, Venbervliet B, Wang Y, Wick G, Wijesundera KK   +32 more
core   +2 more sources

Single-cell sequencing reveals peritoneal environment and insights into fibrosis in CAPD patients [PDF]

, 2023
Wenxue Hu, Guanglan Li, Wei Dong, Peng He, Wei Liu, Yanhua Wu, Huaban Liang, Feng Wen, Yu Feng, Yan Yin, Zhiming Ye, Wenke Hao, Xinling Liang   +12 more
openalex   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source