Results 191 to 200 of about 71,423 (312)

Molecular therapy for peritoneal fibrosis : targeting the TGF-β/Smad signaling pathway

, 2007
Hong Guo
openalex   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study emphasizes the role of the Mapk13‐Tcf1‐Slc7a5‐methionine metabolism axis in stem‐like CD4+ T cells. Moreover, it uncovers the mechanism through which limiting one‐carbon metabolism in CD4+ stem‐like T cells suppresses the tide of chronic allograft vasculopathy, offering potential targets to promote long‐term graft survival.
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen   +8 more
wiley   +1 more source

Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway. [PDF]

Sci Rep
Liu J, Xu X, Zhang L, Jiang T, Zhao Z, Xiao J.   +5 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

A Novel Inhibitor of Methyltransferase SMYD2, AZ505 Protects Against Peritoneal Fibrosis in Mice. [PDF]

Clin Exp Pharmacol Physiol
Xu T, Cui B, Liu F, Liu M, Hou X, Hong X, Qi H.   +6 more
europepmc   +1 more source

Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho. [PDF]

Ren Fail, 2023
Wang Q, Sun J, Wang R, Sun J.
europepmc   +1 more source

Importance of human peritoneal mesothelial cells in the progression, fibrosis, and control of gastric cancer: inhibition of growth and fibrosis by tranilast [PDF]

, 2017
Hiroto Saito, Sachio Fushida, Shinichi Harada, Tomoharu Miyashita, Katsunobu Oyama, Takahisa Yamaguchi, Tomoya Tsukada, Jun Kinoshita, Hidehiro Tajima, Itasu Ninomiya, Tetsuo Ohta   +10 more
openalex   +1 more source

The mechanism of Astragalus membranaceus in treating peritoneal fibrosis by intervening the key syndrome and pathology based on Q-marker theory

, 2022
Xin Liu, QianCheng Liu, Liang Li, GuangWen Chen, Lifeng Meng, Peng Zeng   +5 more
openalex   +1 more source

Safety and Feasibility of Laparoscopic and Endoscopic Cooperative Surgery With Endoscopic Submucosal Dissection for Large Superficial Non‐Ampullary Duodenal Epithelial Tumors

Annals of Gastroenterological Surgery, Volume 10, Issue 2, Page 460-469, March 2026.
ABSTRACT Background and Aims Endoscopic submucosal dissection (ESD) for large superficial non‐ampullary duodenal epithelial tumors (SNADETs) poses substantial technical challenges, primarily because of a heightened risk of adverse events (AEs). Laparoscopic and endoscopic cooperative surgery (D‐LECS) was introduced to address these risks, with recent ...
Masaru Hayami, Shoichi Yoshimizu, Naoki Miyazaki, Shintaro Yamamoto, Hiroyuki Yamamoto, Motonari Ri, Rie Makuuchi, Tomoyuki Irino, Manabu Takamatsu, Souya Nunobe   +9 more
wiley   +1 more source