Results 181 to 190 of about 1,383,505 (213)

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Prognostic value of 24-hour cultivation of peritoneal fluid to distinguish complicated from uncomplicated acute appendicitis: a prospective cohort study. [PDF]

Langenbecks Arch Surg
Mark-Christensen A, Bro Sørensen D, Qvist N, Justesen US, Möller S, Ellebæk MB.   +5 more
europepmc   +1 more source

Adhesive Bowel Obstruction Following Discontinuation of Gastrografin: Time for an Alternative Pathway

ANZ Journal of Surgery, EarlyView.
Omar Abu Saadeh, Hugo C. Temperley, Padraig Cronin, Zi Qin Ng   +3 more
wiley   +1 more source

A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy

Clinical Genetics, EarlyView.
PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady, Hadar Hulin Ma'ayan, Michal Cohen, Karin Weiss   +3 more
wiley   +1 more source

Surgical removal of a perirectal melanoma through sphincterotomy and rectal wall resection in a horse

Equine Veterinary Education, EarlyView.
Summary Melanomas are among the most frequent neoplasms in grey horses. Deep perirectal melanomas, however, are uncommon and challenging to excise due to their proximity to the peritoneal reflection. This report describes the successful standing removal of a large (16 × 8 × 6 cm) perirectal melanoma firmly adherent to the dorsal rectal wall in a 19 ...
R. Becker, C. Koch, M. de Preux
wiley   +1 more source

Peritoneal fluid indocyanine green test for diagnosis of gut leakage in anastomotic leakage rats and colorectal surgery patients. [PDF]

World J Gastrointest Surg
Huang Y, Li TY, Weng JF, Liu H, Xu YJ, Zhang S, Gu WL.   +6 more
europepmc   +1 more source

Should equine practitioners still prescribe chloramphenicol for treating horses?

Equine Veterinary Education, EarlyView.
Summary Background Clinical breakpoints for chloramphenicol are not currently available to test susceptibility of bacteria isolated from horses. Without these breakpoints, testing the susceptibility of bacterial isolates from horses cannot be interpreted properly.
M. G. Papich, L. A. Gunnett, M. N. Martinez   +2 more
wiley   +1 more source

Clinical and surgical findings in a mare with unilateral ovarian fibroleiomyoma and adhesions

Equine Veterinary Education, EarlyView.
Summary This case report describes the clinical presentation, ultrasonographic findings, surgical management and outcome of a 7‐year‐old Warmblood mare presented for recurrent colic, weight loss and poor performance. Rectal palpation identified a firm mass in the left caudal abdomen, which appeared on ultrasonography as a large, fluid‐filled, cyst‐like
N. Scilimati, P. Berni, E. Blanc, M. Di Pentima, F. Leonardi, S. Napoli, C. Palmieri, M. Ruggeri, R. Gialletti   +8 more
wiley   +1 more source

Ectopic pregnancy in a horse

Equine Veterinary Education, EarlyView.
Summary An ectopic fetus was discovered in the abdominal cavity of a 21‐year‐old Haflinger mare, which was referred to an equine clinic because of colic symptoms. The mare had been inseminated 3 years previously and was confirmed pregnant at 90 days.
M. S. Swoboda, A. K. Rötting, H. Sieme, J. Sielhorst   +3 more
wiley   +1 more source

Intraperitoneal Dedifferentiated Liposarcoma: Unveiling a Rare Diagnosis in Peritoneal Fluid Cytology - A Case Report with Literature Review.

Acta Cytol
Prabhu S, Monappa V, Kumar NAN, Suvarna N, Godkhindi VM.   +4 more
europepmc   +1 more source