Results 31 to 40 of about 1,383,505 (213)

SGLT2 inhibition does not reduce glucose absorption during experimental peritoneal dialysis [Elektronisk resurs]

, 2021
Introduction: Unwanted glucose absorption during peritoneal dialysis (PD) remains a clinical challenge, especially in diabetic patients. Recent experimental data indicated that inhibitors of the sodium and glucose co-transporter (SGLT)-2 could act to ...
Öberg, Carl M.,, Martus, Giedre,, de Arteaga, Javier,, Lund University., Bergling, Karin,   +4 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Peritoneal inflammation precedes encapsulating peritoneal sclerosis: results from the GLOBAL fluid study

, 2016
Background Encapsulating peritoneal sclerosis (EPS) is an uncommon condition, strongly associated with a long duration of peritoneal dialysis (PD), which is itself associated with increased fibrosis in the peritoneal membrane. The peritoneal membrane is
Lambie, Mark R., Chess, James, Williams, Paul Ford, GLOBAL Fluid Study Investigators, Davies, Simon J., Summers, Angela M., Topley, Nicholas   +6 more
core   +1 more source

Cytokines in peritoneal fluid of ovarian neoplasms

, 2020
The aim of this study was to evaluate cytokine levels (IL-2, IL-8, TNF-α, IL-5, IL-6 and IL-10) in the peritoneal fluid in non-neoplastic tumours, benign ovarian neoplasms and malignant ovarian neoplasms.
Agrimaldo Martins-Filho, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini, Isac Souza Silva Rodrigues, Douglas Côbo Micheli, Cid Almeida de Lima, Beatriz Martins Tavares-Murta   +6 more
core   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Peritoneal Fluid - 3

, 2018
An image from a peritoneal fluid cytospin slide demonstrating macrophages, monocytes, polymorphonuclear cells, lymphocytes, and mesothelial cells (20X)
To, Michelle, Kwon, Gloria
core   +1 more source

The peritoneal tumour microenvironment of high-grade serous ovarian cancer [PDF]

, 2012
High-grade serous ovarian cancer (HGSC) disseminates early and extensively throughout the peritoneal space, causing multiple lesions that are a major clinical problem. The aim of this study was to investigate the cellular composition of peritoneal tumour
Balkwill, F.R., Felicity N. E Gavins, Gould, D, Balkwill, FR, McNeish, IA, Gavins, F.N.E., Kulbe, H., Nourshargh, S., Perretti, M, Iain A McNeish, Perretti, M., Cooper, D., Thompson, R., Leinster, DA, D Andrew Leinster, Darren P Ennis, Richard Thompson, Gavins, FNE, Ennis, DP, Gemma Everitt, Dianne Cooper, Kulbe, H, Lockley, M, Nourshargh, S, Mauro Perretti, Mcneish, I.A., Lockley, M., Michelle Lockley, Everitt, G, Ennis, D.P., Frances R Balkwill, Gould, D., Leinster, D.A., Cooper, D, Sussan Nourshargh, Thompson, R, Hagen Kulbe, David Gould, Everitt, G.   +38 more
core   +1 more source

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

Diagnostic Peritoneal Lavage : an obituary? [PDF]

, 2006
Diagnostic peritoneal lavage (DPL) has been used as a diagnostic procedure in patients with blunt abdominal trauma for almost a century. Its accuracy and reliability are high.
Cassar, Kevin
core  

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source