Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li +4 more
wiley +1 more source
A case of abdominal sarcoidosis in a patient with acute myeloid leukemia. [PDF]
The allogeneic bone marrow transplantation usually preceded by induction chemotherapy, in fit patients, represents the gold standard in the acute myeloid leukaemia.
Addeo, Alfredo +4 more
core +2 more sources
The Role of Macrophages in Cancer: From Basic Research to Clinical Applications
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu +5 more
wiley +1 more source
Sarcomatoid mesothelioma (SM) is the rarest subtype of malignant mesothelioma (MM) with the poorest prognosis. Due to its aggressive nature, early diagnosis and treatment are required for SM, resulting in they significantly improve patient survival ...
Yuri Noda +3 more
doaj +1 more source
Pediatric Peritoneal Epithelial Malignant Mesothelioma Case Report
We present a 14-year-old boy with peritoneal epithelial malignant mesothelioma (PEMM). While pathology is required to make this diagnosis, radiology plays a crucial role throughout the clinical course of this disease.
Elizabeth Bellew +5 more
doaj +1 more source
Effusion‐Dominant Pulmonary Sarcomatoid Carcinoma Without a Primary Mass: A Case Report
We describe a patient with high‐grade sarcomatoid carcinoma presenting as malignant pleural effusion without a primary mass. This case highlights the diagnostic challenges, aggressive clinical course, and importance of early biopsy. We also review the limited literature describing similar presentations.
Sze Kye Teoh +5 more
wiley +1 more source
Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report
Key Clinical Message Malignant peritoneal mesothelioma, a rare and poor prognosis disease, is seldom treated surgically, especially for recurrence. However, early diagnosis and aggressive treatment of primary and recurrent tumors can achieve long‐term ...
Takashi Miyata +15 more
doaj +1 more source
Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells [PDF]
BACKGROUND: The asbestos-like toxicity of some engineered carbon nanotubes (CNT), notably their capacity to induce mesothelioma, is a serious cause of concern for public health.
Christian Bailly +14 more
core +3 more sources
Multicystic peritoneal mesothelioma.
Multicystic peritoneal mesothelioma is a rare disease. It is not certain if it is a benign or a borderline tumor. Although many therapeutic approaches have been used, complete cytoreductive surgery in combination with hyperthermic intraoperative intraperitoneal chemotherapy has gained acceptance.A case of multicystic peritoneal mesothelioma in a 16 ...
Tentes, Antonios-Apostolos +3 more
openaire +2 more sources
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin in pediatric patients with peritoneal mesothelioma: a single institution experience and long term follow up [PDF]
Parisa Malekzadeh +2 more
openalex +1 more source

