Results 61 to 70 of about 6,029 (212)

Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA

Scientific oral presentations, 2021
Introduction High-risk plaque (HRP) features on coronary computed tomography angiography (CCTA) are indicators of increased cardiac risk. Coronary inflammation induces spatial changes in perivascular adipose tissue (PVAT) composition, which can be quantified with the perivascular Fat Attenuation Index (FAI).
Kotanidis, CP, Oikonomou, EK, Marwan, M, Kluener, L, Thomas, KE, Alashi, A, Antonopoulos, AS, Shirodaria, C, Neubauer, S, Channon, KM, Achenbach, S, Desai, MY, Antoniades, C   +12 more
openaire   +2 more sources

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Advanced Science, EarlyView.
A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang, Beiyuan Gao, Haiyang Xu, Cheng Huang, Kaili Lin, Yuanzhi Xu, Peiqi Zhu   +9 more
wiley   +1 more source

Usefulness of fat attenuation index in postmortem CT for identifying responsible vessels in acute coronary syndromes: A case report

Radiology Case Reports
Postmortem imaging, particularly unenhanced postmortem computed tomography (PMCT), has been increasingly utilized for pathological or judicial examination as a substitute for conventional autopsy, to compensate very low autopsy rates.
Tomoya Kobayashi, RT, PhD, Junji Mochizuki, RT, MSc, Kazuya Tashiro, RT, Hajime Saitou, RT, Masahiro Yoshida, RT, Kazunori Kaga, RT, Ryusei Inamori, RT, MSc, Hideyuki Hayakawa, MD, PhD, Takahisa Okuda, MD, PhD, Yoshikazu Okamoto, MD, PhD   +9 more
doaj   +1 more source

Somatic PDGFRB activating variants in fusiform cerebral aneurysms [PDF]

, 2019
The role of somatic genetic variants in the pathogenesis of intracranial-aneurysm formation is unknown. We identified a 23-year-old man with progressive, right-sided intracranial aneurysms, ipsilateral to an impressive cutaneous phenotype.
Alcantara, Diana, Busald, Tina, Byers, Peter, Dobyns, William B, Dorschner, Michael O, Ferreira, Manuel, Gonzalez-Cuyar, Luis F, Hale, Christopher J, Karasozen, Yigit, Kim, Louis J, Murray, Mitzi, O'Driscoll, Mark, Osbun, Joshua W, Parada, Carolina Angelica, Tatman, Philip   +14 more
core   +1 more source

The histopathological correlate of peri-vascular adipose tissue attenuation on computed tomography in surgical ascending aorta aneurysms: Is this a measure of tissue inflammation? [PDF]

, 2021
On computed tomography (CT) imaging, a peri-vascular adipose tissue attenuation (pVAT) measure has been proposed as a non-invasive correlate of inflammation in the coronary artery vessels, and a single research group provided histopathological ...
Corradi D., De Filippo M., Gaibazzi N., Gallingani A., Maestri F., Martini C., Nicolini F., Sartorio D., Tafuni A., Tuttolomondo D.   +9 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Galectin-3. One molecule for an alphabet of diseases, from A to Z [PDF]

, 2018
Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix interactions, growth, proliferation, differentiation, and inflammation.
Bellotti, Carlo, De Francesco, Gian Paolo, Lavra, Luca, Magi, Fiorenza, Morgante, Alessandra, Ricci, Alberto, Salehi, Leila B., Sciacchitano, Salvatore, Ulivieri, Alessandra   +8 more
core   +2 more sources

Phase‐Change Assembling Nanostructures Synergistically Potentiate Tumor Radiosensitivity by Reducing the Stemness of Cancer Stem‐Like Cells

Exploration, EarlyView.
A eutectic phase‐change mixture of natural fatty acids was introduced to serve as a gating material for the near‐infrared‐triggered precise release of oxygen and nitroimidazole radiosensitizer in tumors. The stemness of cancer stem‐like cells was shown to be significantly reduced through the delivery of oxygen to deep tumors.
Yuanfang Chen, Xueyin Hu, Ze Hu, Yuwei Yang, Changfen Bi, Guangyou Shi, Lumeng Zhang, Wenqing Xu, Shuqin Li, Luntao Liu   +9 more
wiley   +1 more source

Coronary Computed Tomography Angiography (CTA) Findings in COVID-19

Journal of Cardiovascular Development and Disease
(1) Background: The novel SARS-CoV-2 virus infects the endothelium. Vasculitis may lead to specific coronary artery wall lesions. Coronary computed tomography angiography (CTA) imaging findings have not been systematically reported. The aim of this study
Pietro G. Lacaita, Anna Luger, Fabian Plank, Fabian Barbieri, Christoph Beyer, Theresa Thurner, Yannick Scharll, Johannes Deeg, Gerlig Widmann, Gudrun M. Feuchtner   +9 more
doaj   +1 more source