Results 71 to 80 of about 6,029 (212)

Determinants of vessel contrast in BMI-adapted low dose CT coronary angiography with prospective ECG-triggering [PDF]

, 2018
We evaluated the determinants of vessel contrast in prospectively ECG-triggered CT coronary angiography (CTCA). Seventy patients underwent low-dose CTCA using Body Mass Index (BMI)-adapted tube parameters and a fixed contrast material bolus.
Burkhard, Nina, Gaemperli, Oliver, Herzog, Bernhard, Husmann, Lars, Kaufmann, Philipp, Landmesser, Ulf, Tay, Fabian, Valenta, Ines, Wyss, Christophe   +8 more
core  

Silencing of the Na+/H+ exchanger 1(NHE-1) prevents cardiac structural and functional remodeling induced by angiotensin II [PDF]

, 2019
Chronic activation of the renin angiotensin system (RAS) favors several cardiac diseases, among which myocardial hypertrophy occupies an outstanding place. In this context, the hyperactivity of the cardiac Na+/H+ (NHE-1) exchanger plays a key role.
Caldiz, Claudia Irma, Ennis, Irene Lucia, Medina, Andrés Javier, Pinilla, Oscar Andres, Portiansky, Enrique Leo   +4 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device [PDF]

, 2021
Aims: Coronary computed tomography angiography (CCTA) is a first-line modality in the investigation of suspected coronary artery disease (CAD). Mapping of perivascular fat attenuation index (FAI) on routine CCTA enables the non-invasive detection of ...
Achenbach, S, Antoniades, C, Antonopoulos, AS, Channon, KM, Deanfield, J, Desai, MY, Fava, A, Kluner, L, Marwan, M, Mathers, C, Mavrogiannis, MC, Neubauer, S, Oikonomou, EK, Schottlander, D, Shirodaria, C, Siddique, M, Thomas, S, Tomlins, P   +17 more
core  

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Advances in Clinical Imaging of Vascular Inflammation

JACC: Basic to Translational Science
Summary: Vascular inflammation is a major contributor to cardiovascular disease, particularly atherosclerotic disease, and early detection of vascular inflammation may be key to the ultimate reduction of residual cardiovascular morbidity and mortality ...
Henry W. West, BMedSci, MBBS, PhD, Katerina Dangas, BA, Charalambos Antoniades, MD, PhD   +2 more
doaj   +1 more source

Assessment of coronary artery outward remodeling in consequence of excision of epicardial adipose tissue in Ossabaw swine [PDF]

, 2017
Background Coronary artery disease (CAD) results from the buildup of cholesterol, inflammatory factors, and proliferating smooth muscle cells within a vessel wall. This plaque impedes on the vessel lumen, decreasing the space through which blood can flow,
Coderre, Kelly
core   +1 more source

Imaging residual inflammatory cardiovascular risk [PDF]

, 2019
Targeting residual cardiovascular risk in primary and secondary prevention, would allow deployment of novel therapeutic agents, facilitating precision medicine.
Antoniades, C, Antonopoulos, AS, Deanfield, J   +2 more
core   +2 more sources

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source