Results 251 to 260 of about 16,443 (268)
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PerleCan fix your muscle AChEs
Trends in Neurosciences, 2003Efficient and accurate synaptic transmission requires proper localization of numerous signaling proteins in the synaptic membrane. At the neuromuscular junction, the nicotinic ACh receptor mediates postsynaptic depolarization, and acetylcholinesterase (AChE) terminates this process by hydrolyzing ACh.
Michelle S. Steen, Stanley C. Froehner
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Perlecan: A gem of a proteoglycan
Matrix Biology, 1994Perlecan, the main proteoglycan of basement membranes and pericellular spaces, is one of the largest single-chain polypeptides of vertebrate animals. The five modules of perlecan are collated from protein building blocks evolutionarily related to molecules involved in nutrient metabolism, mitogenesis and adhesion.
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Role of perlecan in skeletal development and diseases
Glycoconjugate Journal, 2002Perlecan, a large heparan sulfate proteoglycan (HSPG), is present in the basement membrane and other extracellular matrices. Its protein core is 400 kDa in size and consists of five distinct structural domains. A number of in vitro studies suggest multiple functions of perlecan in cell growth and differentiation and tissue organization.
Eri Arikawa-Hirasawa +2 more
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2012
Chapter 26 covers disorders of the Perlecan group (dyssegmental dysplasia, Silverman-Handmaker type (MIM 224410), dyssegmental dysplasia, Rolland-Desbuquois type (MIM 224400), Schwartz-Jampel syndrom (MIM 255800)) , including major clinical findings, radiographic features, and differential diagnoses.
Jürgen W. Spranger +4 more
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Chapter 26 covers disorders of the Perlecan group (dyssegmental dysplasia, Silverman-Handmaker type (MIM 224410), dyssegmental dysplasia, Rolland-Desbuquois type (MIM 224400), Schwartz-Jampel syndrom (MIM 255800)) , including major clinical findings, radiographic features, and differential diagnoses.
Jürgen W. Spranger +4 more
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Colocalization in vivo and association in vitro of perlecan and elastin
Histochemistry and Cell Biology, 2011We have colocalized elastin and fibrillin-1 with perlecan in extracellular matrix of tensional and weight-bearing connective tissues. Elastin and fibrillin-1 were identified as prominent components of paraspinal blood vessels, and posterior longitudinal ligament in the human fetal spine and outer annulus fibrosus of the fetal intervertebral disc.
Anthony James Hayes +6 more
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Function of Perlecan Domain I in Prostate Cancer [PDF]
, 2005 Abstract : Perlecan (Pln), the major heparan sulfate proteoglycan (HSPG) in the bone marrow stromal ECM functions as a permissive ECM molecule, or co-receptor, that delivers HBGF's to high affinity receptors. Heparan sulfate chains on Pln are located in a unique N-terminal domain I (PlnDI) which functions as the co-receptor for HBGFs. Our purpose is to
Chu Zhang +3 more
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Role of Collagen Type II and Perlecan in Skeletal Development
Annals of the New York Academy of Sciences, 2003Abstract: The cartilage extracellular matrix is composed of a dense collagen network that entraps a range of other specialized proteins important for the proper formation and function of the tissue. Loss of two abundant cartilage components, type II collagen and perlecan, has drastic effects on skeletal development.
Hans-Werner Denker +7 more
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Focus on Molecules: Perlecan (HSPG2)
Experimental Eye Research, 2006Simone M. Smith, John R. Hassell
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