Results 31 to 40 of about 22,074 (268)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The H/C Molar Ratio and Its Potential Pitfalls for Determining Biochar's Permanence

GCB Bioenergy
Biochar carbon removal (BCR) is widely recognized as a globally feasible technique for removing CO2 from the atmosphere and storing carbon in a stable form within the environment.
Henrik I. Petersen, Hamed Sanei
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Dynamics for a discrete competition and cooperation model of two enterprises with multiple delays and feedback controls

Open Mathematics, 2017
This paper is concerned with a competition and cooperation model of two enterprises with multiple delays and feedback controls. With the aid of the difference inequality theory, we have obtained some sufficient conditions which guarantee the permanence ...
Lu Lin, Lian Yi, Li Chaoling
doaj   +1 more source

Introduction of the Institutionally Guaranteed Judicial Independence into Serbian Law [PDF]

Zbornik Radova Pravnog Fakulteta u Nišu
The paper deals with the issue of introducing institutional guarantees of judicial independence into Serbian law. The institutional guarantee of judicial independence implies the permanence, immovability and financial security of judicial positions.
Gavrilović-Grbović Biljana
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Forest protection and permanence of reduced emissions

Frontiers in Forests and Global Change, 2022
Tropical forests are essential for climate change mitigation. With growing interest over the use of credits from reducing emissions from deforestation and forest degradation (REDD+) and other natural climate solutions within both voluntary and compliance
Margaret McCallister, Andrey Krasovskiy, Anton Platov, Breno Pietracci, Alexander Golub, Ruben Lubowski, Gabriela Leslie   +6 more
doaj   +1 more source

A Note on Permanents [PDF]

Canadian Mathematical Bulletin, 1971
Let A = (aij) be an m × n matrix and let K = {s1, …, sk} be a k-subset from {1, 2, …, n}. For 0≤t≤k≤n define the (t, K)-permanent of A to be(1)the summation taken over all m-tuples (i1, i2, …, im) (repetitions allowed) of 1, 2, …, n each containing exactly t distinct entries from K and any number of distinct entries from the remaining n-k integers. For
openaire   +2 more sources