Results 51 to 60 of about 1,188,292 (298)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

A Vectorial Approach for Generation of Optimal Current References for Multiphase Permanent-Magnet Synchronous Machines in Real Time [PDF]

, 2011
This paper deals with the generation of optimal current references for multiphase permanent-magnet (PM) synchronous machines in normal or fault mode (open-circuited phases).
KESTELYN, Xavier, SEMAIL, Eric, Eric Semail, Xavier Kestelyn   +3 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Analysis of Negative-Saliency Permanent-Magnet Machines

IEEE Transactions on Industrial Electronics, 2010
In this paper, a negative-saliency permanent-magnet (PM) synchronous machine analysis is presented. This particular saliency feature is achieved by replacing a portion of the magnet material by a soft iron piece over the rotor pole. In this manner, the d-axis inductance is increased, whereas the q-axis inductance is almost not affected, leading to the ...
Roberto H. Moncada, Juan A. Tapia, Thomas M. Jahns   +2 more
openaire   +3 more sources

Multipolar SPM machines for direct drive application: a comprehensive design approach [PDF]

, 2012
A closed-form, per-unit formulation is proposed, for the design of surface mounted permanent magnet motors with high number of poles. The model evaluates the shear stress, the power factor and the specific Joule loss as the indicators of the machine ...
B. Boazzo, Pellegrino, Gian-Mario Luigi, A. Vagati, Vagati, Alfredo, PELLEGRINO, GIAN - MARIO LUIGI, G. Pellegrino, Boazzo, Barbara   +6 more
core   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Computation of Optimal Current References for Flux-weakening of Multi-Phase Synchronous Machines [PDF]

, 2012
Multi-phase synchronous machines are more and more used in specific applications where high power density, low bus voltage, wide speed range and fault-tolerant capabilities are required. Due to the high number of degrees of freedom, multi-phase machines
Bassel Aslan, LU, Li, ASLAN, Bassel, Paul Sandulescu, Eric Semail, SANDULESCU, Paul, MEINGUET, Fabien, Li Lu, KESTELYN, Xavier, F. Meinguet, Luc Kobylanski, SEMAIL, Eric, KOBYLANSKI, Luc, Xavier Kestelyn   +13 more
core   +1 more source

Clinical Validation of Artificial Intelligence (AI)‐based Cartilage Segmentation Predicting Knee Replacement

Arthritis Care &Research, Accepted Article.
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein, David J. Hunter, C. Kent Kwoh, Wolfgang Wirth   +3 more
wiley   +1 more source

Torque behavior of one-phase permanent magnet AC motor [PDF]

, 2006
This paper presents a detailed comparative study of two starting and running methods for a single-phase permanent magnet synchronous motor, equipped with a squirrel-cage rotor. The analysis of the motor performance is realized for a pulse width modulated
McGilp, M.I., Miller, T.J.E., Trivillin, N., Strappazzon, G., Popescu, M., Santarossa, R.   +5 more
core   +1 more source