Results 71 to 80 of about 785,846 (238)

Project Artemis [PDF]

open access: yes
The goals of Project Artemis are designed to meet the challege of President Bush to return to the Moon, this time to stay. The first goal of the project is to establish a permanent manned base on the Moon for the purposes of scientific research and ...
Akin, David   +3 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The efficiency of nutrient utilization by permanent grassland in the Kameničky locality

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013
This work presents the analysis of the effect of grassland management on leaching of mineral nitrogen from rhizosphere and plant biomass production in area of our interest. The determined values show the influence of fertilization and species composition
Adam Nawrath   +4 more
doaj   +1 more source

The 21st century propulsion [PDF]

open access: yes
The prediction of future space travel in the next millennium starts by examining the past and extrapolating into the far future. Goals for the 21st century include expanded space travel and establishment of permanent manned outposts, and representation ...
Boehmer, C., Haloulakos, V. E.
core   +1 more source

Family farming in the agricultural census of 2006: the legal mark and the options for their identification. [PDF]

open access: yes, 2010
(Agricultura familiar no censo agropecuário 2006: o marco legal e as opções para sua identificação). Visando delimitar a agricultura familiar no Censo Agropecuário 2006, o Ministério do Desenvolvimento Agrário (MDA) e o Instituto Brasileiro de Geografia ...
Grossi, Mauro Eduardo Del   +1 more
core  

Entry and productivity growth: evidence from microlevel panel data [PDF]

open access: yes, 2004
How does entry affect productivity growth of incumbents? In this paper we exploit policy reforms in the United Kingdom that changed entry conditions by opening up the U.K. economy during the 1980s and panel data on British establishments to shed light on
Aghion, [Unknown]   +5 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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