Results 51 to 60 of about 66,714 (266)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Reemerging Sudan Ebola Virus Disease in Uganda, 2011

Emerging Infectious Diseases, 2012
Two large outbreaks of Ebola hemorrhagic fever occurred in Uganda in 2000 and 2007. In May 2011, we identified a single case of Sudan Ebola virus disease in Luwero District.
Trevor Shoemaker, Adam MacNeil, Stephen Balinandi, Shelley Campbell, Joseph Francis Wamala, Laura K. McMullan, Robert Downing, Julius Lutwama, Edward Mbidde, Ute Ströher, Pierre E. Rollin, Stuart T. Nichol   +11 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Trait-mediated insect colonization of newly established grassland strips in agricultural landscapes

Basic and Applied Ecology
Restoring grasslands in agroecosystems through the establishment of grassland and flowering strips has been demonstrated to promote insects. However, the development of the functional composition of insect assemblages in newly established grassland ...
Maria Peer, Sophie Kratschmer, Raja Imran Hussain, Manuela Bürgler, Bea Maas, Dominik Rabl, Ronnie Walcher, Tobias Schernhammer, Norbert Schuller, Nora Vogel, Matthias Heer, Simon Zwatz, Bernhard Krautzer, Dietmar Moser, Thomas Frank   +14 more
doaj   +1 more source

Silesians at the Department of Theology of the Krakow University in the 15th century

Folia Historica Cracoviensia, 1996
The establishment of universities in Prague, Vienna and Krakow enabled the Silesians to participate to a greater extent in the university culture of late Middle Ages.
Mieczysław Markowski
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The new permanent establishment

, 2023
The PE is a century-old concept with a fundamental role in the international taxation system via the fair allocation of taxing rights over cross-border business profits within the source-residence principles equilibrium, as a vital threshold for source taxation. Throughout its existence, this pivotal element has relied on its founding principles, which
openaire   +1 more source

Potential Invasion Risk of Empoasca fabae in China Under CMIP6 Scenarios: Integrating Climatic Suitability and Host Plant Distribution

Agronomy
Empoasca fabae (Harris) is a destructive migratory pest threatening potato cultivation globally. As climate change may facilitate its invasion into China, the world’s largest potato producer, projecting its potential range is critical for early warning ...
Zhendong Gao, Zhuoman Zhang, Hu Li
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source