Results 71 to 80 of about 1,463,922 (294)

The new permanent establishment

, 2023
The PE is a century-old concept with a fundamental role in the international taxation system via the fair allocation of taxing rights over cross-border business profits within the source-residence principles equilibrium, as a vital threshold for source taxation. Throughout its existence, this pivotal element has relied on its founding principles, which
openaire   +1 more source

Potential Invasion Risk of Empoasca fabae in China Under CMIP6 Scenarios: Integrating Climatic Suitability and Host Plant Distribution

Agronomy
Empoasca fabae (Harris) is a destructive migratory pest threatening potato cultivation globally. As climate change may facilitate its invasion into China, the world’s largest potato producer, projecting its potential range is critical for early warning ...
Zhendong Gao, Zhuoman Zhang, Hu Li
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Topographical map, Indonesia, 1:50 000 [cartographic material] /

, 1999
Ed. 1. Map series of East Timor showing buildings and installations, transportation, agriculture, administrative boundaries, and waterways. Relief shown by contours and spot heights.; "Contour interval: 12.5 metres"; "This map was derived from Indonesian
Army Topographic Support Establishment (Australia)
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Critical analysis of the concepts 'permanent establishment' and 'foreign business establishment' [PDF]

, 2012
CITATION: Van Schalkwyk, L. & Van Schaik, R. 2012. Critical analysis of the concepts 'permanent establishment' and 'foreign business establishment'.
Van Schaik, Rozelle, Van Schalkwyk, Linda   +1 more
core   +1 more source

Permanent vascular access in patients with end-stage renal disease, Brazil

Revista de Saúde Pública, 2011
OBJECTIVE: To assess factors associated with the establishment of permanent vascular access for patients with end-stage renal disease. METHODS: Cross-sectional study conducted in a nationally representative sample of Brazilian end-stage renal disease ...
Gisele Macedo da Silva, Isabel Cristina Gomes, Eli Iola Gurgel Andrade, Eleonora Moreira Lima, Francisco de Assis Acurcio, Mariângela Leal Cherchiglia   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source