Results 61 to 70 of about 1,462,409 (293)

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

The Establishment of a Permanent Fire Brigade in Peterhof

open access: yesВестник Северного (Арктического) федерального университета: Серия «Гуманитарные и социальные науки»
This article covers the history of the establishment of such an important organization for any town as a fire service. The author notes that it was initiated by the head of the local palace administration Ya.Ya.
Andrey A. Efimov
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

La clef de la formation professionnelle offerte en milieu scolaire /

open access: yes, 1990
"Cet avis a été adopté par le Conseil permanent de la jeunesse à sa 14e séance, le 24 mars 1990"Bibliogr.: p. 41-43Notes bibliogr.
Québec (Province). Conseil permanent de la jeunesse   +1 more
core   +1 more source

Reemerging Sudan Ebola Virus Disease in Uganda, 2011

open access: yesEmerging Infectious Diseases, 2012
Two large outbreaks of Ebola hemorrhagic fever occurred in Uganda in 2000 and 2007. In May 2011, we identified a single case of Sudan Ebola virus disease in Luwero District.
Trevor Shoemaker   +11 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

The service permanent establishment as defined by OECD An alternative to soften the permanent establishment concept

open access: yes, 2012
Diese Arbeit beschäftigt sich mit der Entwicklung zur Dienstleistungsbetriebsstätte iSd OECD. Ausgehend vom innerstaatlichen Recht wird der Begriff der Betriebsstätte iSd BAO untersucht, um anschließend die Definition und Funktion des ...
Wiechenthaler, Kurt
core   +2 more sources

Trait-mediated insect colonization of newly established grassland strips in agricultural landscapes

open access: yesBasic and Applied Ecology
Restoring grasslands in agroecosystems through the establishment of grassland and flowering strips has been demonstrated to promote insects. However, the development of the functional composition of insect assemblages in newly established grassland ...
Maria Peer   +14 more
doaj   +1 more source

Silesians at the Department of Theology of the Krakow University in the 15th century

open access: yesFolia Historica Cracoviensia, 1996
The establishment of universities in Prague, Vienna and Krakow enabled the Silesians to participate to a greater extent in the university culture of late Middle Ages.
Mieczysław Markowski
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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