Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Design of High Performance Permanent-Magnet Synchronous Wind Generators
This paper is devoted to the analysis and design of high performance permanent-magnet synchronous wind generators (PSWGs). A systematic and sequential methodology for the design of PMSGs is proposed with a high performance wind generator as a design ...
Chun-Yu Hsiao +2 more
doaj +1 more source
Installation of electric generators on turbine engines [PDF]
The installation of generators on turbine aircraft is discussed. Emphasis is placed on the use of the samarium cobalt generator. Potential advantages of an electric secondary power system at the engine level are listed.
Demel, H. F.
core +1 more source
Reliability comparison of wind turbines with DFIG and PMG drive trains [PDF]
Modern wind turbines vary greatly in their drive train configurations. With the variety of options available, it can be difficult to determine which type is most suitable for on and offshore applications. A large percentage of modern drive trains consist
Carroll, James +2 more
core +1 more source
Variable single-axis magnetic-field generator using permanent magnets [PDF]
We present a design for producing precisely adjustable and alternating single-axis magnetic fields based on nested Halbach dipole pairs consisting of permanent magnets only. Our design allows for three dimensional optical and mechanical access to a region with strong adjustable dipolar fields, is compatible with systems operating under vacuum, and does
Oleg Tretiak +2 more
openaire +5 more sources
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Cost and losses associated with offshore wind farm collection networks which centralise the turbine power electronic converters [PDF]
Costs and losses have been calculated for several different network topologies, which centralise the turbine power electronic converters, in order to improve access for maintenance.
Anaya-Lara, Olimpo, Parker, Max
core +1 more source
Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz +8 more
wiley +1 more source
Inertia response from full-power converter-based permanent magnet wind generators
With a high penetration of wind turbines, the proportion of synchronous generation in the power system will be reduced at times, thus creating operating difficulties especially during frequency events.
John Licari, Janaka Ekanayake, Ian Moore
doaj +1 more source

