Results 161 to 170 of about 831,049 (356)

Exposure–Response Modeling and Simulation to Identify Optimal Mavacamten Posology When Coadministered with CYP3A4 and CYP2C19 Inhibitors in Patients with Obstructive HCM

The Journal of Clinical Pharmacology, EarlyView.
Abstract Mavacamten, a cardiac myosin inhibitor, is primarily metabolized by the cytochrome P450 (CYP) enzymes CYP2C19 and CYP3A4, and coadministration with strong CYP3A4 or CYP2C19 inhibitors was contraindicated in patients with obstructive hypertrophic cardiomyopathy (HCM) in the US Prescribing Information. This study assessed the safety and efficacy
Samira Merali, Haden Bunn, Caroline Sychterz, Manting Chiang, Shilpa Puli, Amy J. Sehnert, Bindu Murthy, Joga Gobburu   +7 more
wiley   +1 more source

Superior transseptal versus left atriotomy approaches in isolated mitral valve surgeryCentral MessagePerspective

JTCVS Open
Objective: The superior transseptal approach to mitral valve surgery offers improved exposure compared with left atriotomy; however, concerns remain regarding postoperative arrhythmias and pacemaker placement.
Zohaib R. Khawaja, BS, Gabriel E. Cambronero, MD, Yusuf M. Aboutabl, BS, Elizabeth C. Wood, MD, James E. Jordan, PhD, Timothy E. Craven, MSPH, Patrick M. Kozak, MD, Prashant D. Bhave, MD, Adrian L. Lata, MD, Edward H. Kincaid, MD, Neal D. Kon, MD, Bartlomiej R. Imielski, MD   +11 more
doaj   +1 more source

A Randomized Crossover Clinical Study to Assess the Effect of Oral Nicotine Pouches Used for Different Durations on Plasma Nicotine Pharmacokinetics in Healthy Oral Pouch Consumers

The Journal of Clinical Pharmacology, EarlyView.
Abstract Oral nicotine pouches (NPs), although addictive and not risk‐free, have potential application for a tobacco harm reduction approach. This study aims to further characterize their ability to deliver nicotine effectively. This randomized seven‐way crossover PK study in healthy oral pouch consumers evaluated 11 and 20 mg NPs used for 10, 20, and ...
David Azzopardi, Elaine Brown, Filimon Meichanetzidis, Stacy Fiebelkorn, Linsey E. Haswell, George Hardie, Michael McEwan   +6 more
wiley   +1 more source

A rare case of permanent pacemaker-induced takotsubo cardiomyopathy in a male patient

, 2022
Imran Moinudddin, Ibrar Anjum, Umer Zia, Muhammad Bila Zia, Sajid Ali   +4 more
openalex   +1 more source

Unexpected Giant Right Coronary Artery Aneurysm Diagnosed by Computed Tomography Angiography in the Emergency Department

Journal of Clinical Ultrasound, EarlyView.
3D Volume Rendering coronary CTA reconstruction showing a giant thrombosed aneurysm of the proximal right coronary artery ABSTRACT Giant coronary artery aneurysms (GCAA) are usually defined as diameter > 8 mm or > 400% of the adjacent normal segment; they are very rare (reported prevalence ≈0.02%).
Stefano Giusto Picchi, Giulia Lassandro, Rosita Comune, Filomena Pezzullo, Stefania Tamburrini, Giulio Cocco, Nino Cocco, Domenico Tafuri, Antonio Corvino   +8 more
wiley   +1 more source

Serial GLS assessments over time in patients with preserved ejection fraction undergoing permanent cardiac pacemaker placement [PDF]

Kuan-Meng Soo, Johnson Ki, K I M Hyun Kuk, Chen Young, K I Young Jae, C H O I Dong Hyun, P A R K Keun Ho   +6 more
openalex   +1 more source

Effect of Permanent Pacemaker Implantation After Valve Surgery on Long-Term Outcomes

, 2021
Mu-Chieh Chi, Kuo‐Chun Hung, Shang‐Hung Chang, Victor Chien‐Chia Wu, An‐Hsun Chou, Yi‐Hsin Chan, Chia‐Pin Lin, Chih‐Hsiang Chang, Pao‐Hsien Chu, Shao‐Wei Chen   +9 more
openalex   +2 more sources

The Sense of Smell (SoS) Atlas: Its Creation and First Application to Investigate COVID‐19 Related Anosmia With a Comprehensive Quantitative MRI Protocol

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The loss of smell (anosmia) has been noted in numerous diseases, including COVID‐19. Inflammatory and microstructural alterations are possible underlying mechanisms of anosmia in COVID‐19. However, no atlas exists to study olfaction and the associated tissue property changes.
Marta Gaviraghi, Eleonora Lupi, Elena Grosso, Andrea Fusari, Mattia Baiguera, Anita Monteverdi, Marco Battiston, Francesco Grussu, Baris Kanber, Ferran Prados Carrasco, Rebecca S. Samson, Janine Makaronidis, Marios C. Yiannakas, Michael S. Zandi, Rachel L. Batterham, Egidio D'Angelo, Fulvia Palesi, Claudia A. M. Gandini Wheeler‐Kingshott   +17 more
wiley   +1 more source

Overview of Diagnostic Ultrasound Safety

Journal of Ultrasound in Medicine, EarlyView.
Ultrasound is widely regarded as a safe imaging modality; however, emerging ultrasound‐based techniques—such as shear wave elastography and contrast‐enhanced ultrasound—operate with varying acoustic output parameters that may approach or exceed traditional diagnostic limits. As these technologies are increasingly integrated into human research studies,
Saubhagya Srivastava, Baihui Yu, David Giraud, Manjiri Dighe, Manish Dhyani, Richard G. Barr   +5 more
wiley   +1 more source

Epicardial permanent pacemaker implantation in the retrosternal space of a 2.3-kg infant [PDF]

, 2018
Bongyeon Sohn, Jae Gun Kwak, Jae Hong Lim, Woong‐Han Kim   +3 more
openalex   +1 more source