Results 101 to 110 of about 1,786,056 (302)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Assuming Personal Responsibility for Improving the Environment: Moving Toward a New Environmental Norm [PDF]
, 2009 There is general agreement that we are nearing the end of achieving major gains in pollution abatement from traditional sources, that a significant portion of the remaining environmental problems facing this country is caused by individual behavior, and ...
Babcock, Hope M.
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
The Existential Passage Hypothesis [PDF]
[Excerpt from “Section 1: Summary of the conclusions”] In Chapter 9, Stewart defends the thesis that if non-reductive physicalism is true, then, contrary to a widespread belief, death does not bring about eternal oblivion, a permanent cessation of the ...
Robert, David
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Veterans and Homelessness [PDF]
, 2009 [Excerpt] The wars in Iraq and Afghanistan brought renewed attention to the needs of veterans, including the needs of homeless veterans. Homeless veterans initially came to the country’s attention in the 1970s and 1980s, when homelessness generally was ...
Perl, Libby
core +11 more sources
A NEW AND MORE PERMANENT METHOD OF MOUNTING AMYLOID SECTIONS, STAINED WITH IODINE. [PDF]
The Lancet, 1900 n ...
openaire +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Optimal design of a set of permanent magnet generators with the same cross-section
Journal of Microwaves, Optoelectronics and Electromagnetic ApplicationsThe optimal design of a set of two permanent magnet generators that share the same cross section to reduce the manufacturing cost is presented using a gradient optimization algorithm.
Renato Carlson, Frederic Wurtz
doaj +1 more source
Heterogeneous life-cycle profiles, income risk and consumption inequality [PDF]
Was the increase in income inequality in the US due to permanent shocks or merely to an increase in the variance of transitory shocks? The implications for consumption and welfare depend crucially on the answer to this question. We use CEX repeated cross-
Giorgio E. Primiceri, Thijs van Rens
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