Results 71 to 80 of about 1,786,056 (302)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Inequality over the Business Cycle: Estimating Income Risk using Micro-Data on Consumption [PDF]

open access: yes
We use CEX repeated cross-section data on consumption and income, to evaluate the nature of increased income inequality in the 1980s and 90s. We decompose unexpected changes in family income into transitory and permanent, and idiosyncratic and aggregate ...
Giorgio Primiceri, Thijs van Rens
core   +3 more sources

Safety profile in a parturient with permanent pacemaker who underwent successive lower segment cesarean section under spinal anesthesia

open access: yesJournal of Obstetric Anaesthesia and Critical Care, 2013
We present an unusual case of a young parturient who was diagnosed to have a complete heart block during her first pregnancy and permanent pacemaker was implanted.
Parul Jindal   +3 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Modeling streamflow sensitivity to climate change in New York City water supply streams using a stochastic weather generator

open access: yesJournal of Hydrology: Regional Studies, 2019
Study region: The New York City water supply watersheds Study focus: This study is a modeling analysis on climate change impact on streamflow using a stochastic weather generator (SWG), a hydrologic model, and downscaled future climate scenarios ...
Rajith Mukundan   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

HUBUNGAN TINGKAT KEPATUHAN PELAKSANAAN PROTAP PERAWATAN LUKA DENGAN KEJADIAN INFEKSI LUKA POST SECTIO CAESAREA (SC) DI RUANG MAWAR I RSUD DR. MOEWARDI SURAKARTA

open access: yesJurnal Berita Ilmu Keperawatan, 2008
Backgraund: Indonesian country have the most negatif dateless accidently, special to infection of wound patient post section caesarea. At Cipto Mangunkusumo Jakarta hospital in 1990 year be present dateless infection of wound 12% is unadulterated ...
Himatusujanah Himatusujanah   +1 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Frozen Section Diagnostic Pitfalls of Sertoli-Leydig Cell Tumor with Heterologous Elements

open access: yesCase Reports in Pathology, 2018
A woman in her sixth decade presented with several months of abdominal cramping, decreased appetite, bloating, and increased constipation. Radiologic imaging revealed a 28 cm, multilocular, heterogeneous cystic neoplasm involving the right adnexa.
Ashley Burris   +2 more
doaj   +1 more source

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