Results 41 to 50 of about 14,998 (281)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Predicting Skin Permeability by means of Computational Approaches : Reliability and Caveats in Pharmaceutical Studies [PDF]

, 2019
© 2019 American Chemical Society.The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters.
Almerico, Anna Maria, Hoffman, Ewelina, Hutter, Victoria, Pecoraro, Beatrice, Traynor, Matthew, Tutone, Marco   +5 more
core   +2 more sources

Empirical predicting permeate flux in skim milk microfiltration

Foods and Raw Materials
Native micellar casein and whey proteins can be obtained from skim milk by microfiltration. It is a popular method that yields high-quality dairy products. The article introduces an empirical approach to predicting the permeate flux value during microfiltration of skim milk.
Dmitriy Mamay, Sergey Babenyshev, Ivan Evdokimov, Angelina Mamay, Vyacheslav Lisitsyn   +4 more
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Machine learning-aided modeling for predicting freshwater production of a membrane desalination system: A long-short-term memory coupled with election-based optimizer

Alexandria Engineering Journal
Membrane desalination (MD) is an efficient process for desalinating saltwater, combining the uniqueness of both thermal and separation distillation configurations.
Mohamed Abd Elaziz, Mohamed E. Zayed, H. Abdelfattah, Ahmad O. Aseeri, Elsayed M. Tag-eldin, Manabu Fujii, Ammar H. Elsheikh   +6 more
doaj   +1 more source

The Elimination of Toluenediamine from Aqueous Solution by Reverse Osmosis [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2019
Toluene diamine (TDA) is a main carcinogenic aromatic pollutant in some industrial wastewater. In this study, the reverse osmosis with DSS-HR98PP as the membrane was employed for the removal of TDA in an aqueous environment.
Aref Shokri
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Modeling and simulation of VMD desalination process by ANN [PDF]

, 2015
YesIn this work, an artificial neural network (ANN) model based on the experimental data was developed to study the performance of vacuum membrane distillation (VMD) desalination process under different operating parameters such as the feed inlet ...
Cao, W., Liu, Q., Mujtaba, Iqbal M., Wang, Y.   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Ultraflitration of wastewater with pretreatment: evaluation of flux decline models [PDF]

, 2008
Three different mathematical models relating the flux decline were investigated to quantify the effects of pretreatment in a membrane filtration system.
Kandasamy, J, Shim, WG, Shon, HK, Vigneswaran, S   +3 more
core   +1 more source