Results 71 to 80 of about 17,793,711 (295)
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Safety and Consistency Verification for a High-level Permission Assignment Constraint [PDF]
Jisuanji gongcheng, 2018 Existing permission assignment constraints pay more attention to ensure the safety,however the availability for the system is ignored.Aiming at this problem,this paper proposes a High-level Permission Assignment (HPA)constraint to satisfy the safety and ...
WANG Zheng,XU Dewu,HAN Jianmin,LU Jianfeng
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
DRAFT Permission System: Applications for interventions to improve resilience of coral reef habitat in the Great Barrier Reef Marine Park [PDF]
, 2018 [Extract] To inform reef intervention activities designed to improve the resilience of coral reef habitats, while ensuring they do not have an adverse impact on the biodiversity, heritage, social or economic values of the Marine ...
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
judicial supervision of early marriage appraisal of the approach of Iranian and Algerian law in the light of precedent and Islamic jurisprudence [PDF]
پژوهشنامه حقوق تطبیقیAccording to the legal system of Iran and Algeria, any marriage before the Marriageable age is subject to the permission of the parents of the child in compliance with the expediency of the child by the court. In Algerian law, such a marriage is possible
Saleh Yamrali +2 more
doaj +1 more source