Results 131 to 140 of about 278,863 (274)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Multi-dimensional EEG analysis reveals distinct neurophysiological patterns in Alzheimer's and frontotemporal dementia. [PDF]

J Neuroeng Rehabil
Cai G, Shi Y, Ma J, Zhang X, Wu W.
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Complex network behavior in epileptic patients treated with Vagus Nerve Stimulation (VNS): VNS responders exhibit a unique pattern, different from VNS non-responders and healthy controls. [PDF]

Front Neurosci
Dolezalova I, Chladek J, Macek M, Chrastina J, Škvařilova T, Burilova P, Erben S, Zatloukalova E, Brazdil M.   +8 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Hippocampal subfield thickness and shape analysis in examining the impact of TDP-43 in primary age-related tauopathy. [PDF]

Alzheimers Dement
Youssef H, Gatto RG, Petersen RC, Reichard RR, Jack CR, Whitwell JL, Josephs KA.   +6 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Permutation Tests Based on the Copula-Graphic Estimator and Their Use for Survival Tree Construction. [PDF]

Stat Med
Baur P, Pauly M, Emura T.
europepmc   +1 more source

On permutable \(n\)-groups

, 1988
An \(n\)-groupoid \((G,f)\) is called \(i\)-permutable iff \(f(x_ 1,...,x_{i- 1},f(x_ 1,...,x_ n),x_ i,...,x_{n-1})=x_ n\), for all \(x_ 1,x_ 2,...,x_ n\in G\) and fixed \(i\in\{1,2,...,n\}\). The authors prove that every such \(n\)-group is \(c\)-derived from a Boolean group.
Dudek, W. A., Stojakovic, Z.
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source