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Pernicious anemia: Pathophysiology and diagnostic difficulties
Journal of Evidence-Based Medicine, 2021Pernicious anemia (PA) is the most common cause of vitamin B12 (cobalamin) deficiency anemia in the world. It is an autoimmune disease, comprising of salient features of autoimmune chronic atrophic gastritis (CAG) and cobalamin deficiency (CD).
Thura Win Htut, K. Thein, T. Oo
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Clinical toxicology, 2020
Context: The clinical consequences of excess vitamin B12 induced by multiple oral doses of cyanocobalamin are not well-known. Case details: A young woman was treated with multiple daily doses of 1 mg of cyanocobalamin for severe pernicious anemia.
Jessica Morales-Gutierrez +3 more
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Context: The clinical consequences of excess vitamin B12 induced by multiple oral doses of cyanocobalamin are not well-known. Case details: A young woman was treated with multiple daily doses of 1 mg of cyanocobalamin for severe pernicious anemia.
Jessica Morales-Gutierrez +3 more
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Vitiligo and Pernicious Anemia
Archives of Dermatology, 1970The incidence of vitiligo in the Danish population was determined to be a little above 1% (1.44%), from the examination of a total of 691 admissions during one day of November 1968 to the Glostrup Hospital. We have tried to clarify the correlation between vitiligo and pernicious anemia by studying more comprehensive series of patients.
Inger Grunnet +3 more
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Do all the patients with vitamin B12 deficiency have pernicious anemia?
Journal of Oral Pathology & Medicine, 2016BACKGROUND Vitamin B12 deficiency may result in pernicious anemia (PA). This study evaluated whether all the patients with vitamin B12 deficiency had PA.
A. Sun +5 more
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Pernicious Anemia Presenting With Pancytopenia and Hemolysis: A Case Report
, 2019Vitamin B12 deficiency is a well-known cause of anemia. Pancytopenia and hemolysis are less frequently observed in vitamin B12 deficiency. Reported is the case of a 58-year-old man who presented with dyspnea on exertion, fatigue, and unintentional weight
E. Gladstone
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HIGH-RISK GASTRIC PATHOLOGY AND PREVALENT AUTOIMMUNE DISEASES IN PATIENTS WITH PERNICIOUS ANEMIA.
Endocrine Practice, 2017OBJECTIVE Pernicious anemia (PA) develops from atrophic gastritis due to autoimmune destruction of parietal cells and results in achlorhydria, vitamin B12 and iron deficiencies, anemia, neurologic deficits, and premalignant and malignant stomach lesions.
J. Hughes +7 more
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Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis.
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2017BACKGROUND Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors.
A. Tun, K. Thein, Z. W. Myint, T. Oo
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PERNICIOUS ANEMIA IN CHILDHOOD
Archives of Pediatrics & Adolescent Medicine, 1946PERNICIOUS anemia is essentially a disease of adults, 1 rarely seen under the age of 30 and beginning more commonly during the fifth decade. It is characterized by a macrocytic anemia, a related degeneration of the mucosa of parts of the gastrointestinal tract with a resultant complete achlorhydria and frequently a related degeneration of the central ...
Dunn Sc, Peterson Jc
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Pernicious Anemia in Childhood
New England Journal of Medicine, 1965PERNICIOUS anemia in childhood is a rare disorder. Only 25 definitely proved cases have been reported in the medical literature.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 To establish this diagnosis, other causes of megaloblastic anemia — folic acid deficiency and vitamin B12 deficiency due to a general or specific intestinal absorptive defect — must be
Graham H. Jeffries +3 more
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Vitamin B12 and pernicious anemia--the dawn of molecular medicine.
New England Journal of Medicine, 2014The clinical observation of the therapeutic effect of liver in patients with the previously uniformly fatal pernicious anemia led to new insights in nutrition, hematopoiesis, and cell biology.
H. Franklin Bunn
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