Results 51 to 60 of about 535,002 (245)
Advanced NanoBiomed ResearchAntimicrobial resistance (AMR) poses a significant challenge in wound management, particularly in ischemic and chronic wounds, which are prone to infection and where traditional treatments often fall short.
Ayden Watt +8 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Hydrogen Peroxide and Water Interaction with Carbon Nitride [PDF]
, 2020 This study aims to understand the behavior of a mixture of water and hydrogen peroxide with effects from a carbon nitride catalyst using classical molecular dynamics.
Klovenski, Mason
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Synthesis and characterization of enzymatically active micrometer protein-capsules
Artificial Cells, Nanomedicine, and Biotechnology, 2021 This work describes a general method for the encapsulation of enzymes with albumin as wall material and the enzyme catalase as prime example. Care was taken for the preparation of biochemically active sub-micrometer particles in order to prevent oxygen ...
Kai Melvin Schakowski +3 more
doaj +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Investigation on Effect of Dried Garlic, Bell Pepper and Tomato Pieces on Oxidation of Extra Virgin Olive Oil and Optimization of the Process by Response Surface Methodology [PDF]
Research and Innovation in Food Science and TechnologyFats and oils provide major part of daily energy but their oxidation have bad effect on organoleptic properties and also might result to the production of toxic compounds such as free radicals.
Niloufar Shariatpanahi +3 more
doaj +1 more source
Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia
Frontiers in Bioengineering and Biotechnology, 2020 Oxygen deficiency resulting from bone fracture-induced vascular disruption leads to massive cell death and delayed osteoblast differentiation, ultimately impairing new bone formation and fracture healing.
Tai-En Hsieh +8 more
doaj +1 more source