Results 21 to 30 of about 1,135,071 (192)

A comparative study of peroxisomal structures in Hansenula polymorpha pex mutants [PDF]

, 2007
In a recent study, we performed a systematic genome analysis for the conservation of genes involved in peroxisome biogenesis (PEX genes) in various fungi.
Koek, Anne,, Veenhuis, Marten,, Komori, Masayuki,, Komori, Masayuki, Klei, Ida J. van der,, Koek, Anne, Veenhuis, Marten, van der Klei, Ida J.; id_orcid, van der Klei, Ida J.   +8 more
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Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. [PDF]

PLoS ONE, 2011
The peroxisome biogenesis disorders (PBDs) are currently difficult-to-treat multiple-organ dysfunction disorders that result from the defective biogenesis of peroxisomes. Genes encoding Peroxins, which are required for peroxisome biogenesis or functions,
Minoru Nakayama, Hiroyasu Sato, Takayuki Okuda, Nao Fujisawa, Nozomu Kono, Hiroyuki Arai, Emiko Suzuki, Masato Umeda, Hiroyuki O Ishikawa, Kenji Matsuno   +9 more
doaj   +1 more source

Pay32p of the Yeast Yarrowia lipolytica Is an Intraperoxisomal Component of the Matrix Protein Translocation Machinery [PDF]

, 1995
Pay mutants of the yeast Yarrowia lipolytica fail to assemble functional peroxisomes. One mutant strain, pay32-1, has abnormally small peroxisomes that are often found in clusters surrounded by membranous material.
Rachubinski, Richard A., Szilard, Rachel K., Rachubinski, Richard A.,, Titorenko, Vladimir I.,, V I Titorenko, R A Rachubinski, Titorenko, Vladimir I., Rachel K. Szilard, M Veenhuis, Veenhuis, Marten,, R K Szilard, Szilard, Rachel K.,, Richard A. Rachubinski, Marten Veenhuis, Veenhuis, Marten, Vladimir I. Titorenko   +15 more
core   +2 more sources

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Ida J. van der Klei, Loknath Gidijala, Kiel, Jan A. K. W., Gidijala, Loknath, Klei, Ida J. van der,, van der Klei, Ida J., Jan A.K.W. Kiel, Veenhuis, Marten,, Gidijala, Loknath,, Kiel, Jan A.K.W.,, Marten Veenhuis, Veenhuis, Marten, van der Klei, Ida J.; id_orcid   +12 more
core   +2 more sources

Peroxisome biogenesis disorders

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
Defects in PEX genes impair peroxisome assembly and multiple metabolic pathways confined to this organelle, thus providing the biochemical and molecular bases of the peroxisome biogenesis disorders (PBD). PBD are divided into two types--Zellweger syndrome spectrum (ZSS) and rhizomelic chondrodysplasia punctata (RCDP).
Steinberg, Steven J., Dodt, Gabriele, Raymond, Gerald V., Braverman, Nancy E., Moser, Ann B., Moser, Hugo W.   +5 more
openaire   +2 more sources

A Study on the Origin of Peroxisomes: Possibility of Actinobacteria Symbiosis [PDF]

, 2008
The origin of peroxisomes as having developed from the endoplasmic reticulum (ER) was proposed on the basis of the similarity between some peroxisomal proteins and ER proteins, and the localization of some peroxisomal proteins on the ER.
Miyata Daisuke, Horiike Tokumasa, Saruhashi Satoshi, Hamada Kazuo, Shinozawa Takao, Duhita Narendra   +5 more
core   +1 more source

Peroxisome biogenesis and peroxisome biogenesis disorders

FEBS Letters, 2000
Peroxisome assembly in mammals requires more than 15 genes. Two isoforms of the peroxisome targeting signal type 1 (PTS1) receptor, Pex5pS and Pex5pL, are identified in mammals. Pex5pS and Pex5pL bind PTS1 proteins. Pex5pL, but not Pex5pS, directly interacts with the PTS2 receptor, Pex7p, carrying its cargo PTS2 protein in the cytosol.
openaire   +3 more sources

Identification of a novel mutation in PEX10 in a patient with attenuated Zellweger spectrum disorder: a case report

Journal of Medical Case Reports, 2017
Background The peroxisome biogenesis disorders, which are caused by mutations in any of 13 different PEX genes, include the Zellweger spectrum disorders.
Maria Blomqvist, Karin Ahlberg, Julia Lindgren, Sacha Ferdinandusse, Jorge Asin-Cayuela   +4 more
doaj   +1 more source

Peroxisome biogenesis in Hansenula polymorpha: different mutations in genes, essential for peroxisome biogenesis, cause different peroxisomal mutant phenotypes [PDF]

, 1992
In Hansenula polymorpha, different monogenic recessive mutations mapped in either of two previously identified genes, PER1 and PER3, produced different peroxisomal mutant phenotypes.
Titorenko, V. I., Harder, Wim, Waterham, H. R., Waterham, Hans R., Haima, Peter, Titorenko, Vladimir I.,, Titorenko, Vladimir I., Harder, Wim,, Haima, Peter,, Veenhuis, Marten,, Veenhuis, M., Veenhuis, Marten, Harder, W., Haima, P., Waterham, Hans R.,   +14 more
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Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata

Journal of Lipid Research, 2012
Many cell surface proteins in mammalian cells are anchored to the plasma membrane via glycosylphosphatidylinositol (GPI). The predominant form of mammalian GPI contains 1-alkyl-2-acyl phosphatidylinositol (PI), which is generated by lipid remodeling from
Noriyuki Kanzawa, Nobuyuki Shimozawa, Ronald J.A. Wanders, Kazutaka Ikeda, Yoshiko Murakami, Hans R. Waterham, Satoru Mukai, Morihisa Fujita, Yusuke Maeda, Ryo Taguchi, Yukio Fujiki, Taroh Kinoshita   +11 more
doaj   +1 more source