Results 61 to 70 of about 1,135,071 (192)

Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease

Life Science Alliance
Peroxisome-mediated cholesterol trafficking is essential for the ciliary localization of the polycystin complex to prevent the occurrence of polycystic kidney.
Takeshi Itabashi, Kosuke Hosoba, Tomoka Morita, Sotai Kimura, Kenji Yamaoka, Moe Hirosawa, Daigo Kobayashi, Hiroko Kishi, Kodai Kume, Hiroshi Itoh, Hideshi Kawakami, Kouichi Hashimoto, Takashi Yamamoto, Tatsuo Miyamoto   +13 more
doaj   +1 more source

Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Mitochondria respond to proteotoxic stress through the mitochondrial unfolded protein response, traditionally viewed as a transcriptional program that restores proteostasis by inducing chaperones and proteases. Emerging evidence indicates that mitochondrial membrane remodeling constitutes an additional adaptive component of this response ...
Lena J. Reichert, F.‐Nora Vögtle, Carlotta Peselj   +2 more
wiley   +1 more source

Peroxisomal protein translocation [PDF]

, 2010
Peroxisomes perform a wide variety of metabolic processes in eukaryotic organisms. Mutations that affect peroxisome function or formation have profound phenotypic consequences, the latter demonstrated by peroxisome biogenesis disorders which are often ...
Saffian, Delia, Erdmann, Ralf, Girzalsky, Wolfgang   +2 more
core   +1 more source

Peroxisomal import stress activates integrated stress response and inhibits ribosome biogenesis [PDF]

Impaired organelle-specific protein import triggers a variety of cellular stress responses, including adaptive pathways to balance protein homeostasis. Most of the previous studies focus on the cellular stress response triggered by misfolded proteins or ...
Kim, Jinoh, Miao, Ting, Bai, Hua, Huang, Kerui, Simons, Mirre J. P., Vo, Pham Thuy Tien, Kumar, Ankur, Correia, Jacinta   +7 more
core   +3 more sources

Estradiol Replacement Modulates Synaptic Transmission‐Related Proteins in the Hippocampus of Ovariectomized Rats: An Exploratory Proteomic Approach

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
The estrogen deficiency in the hippocampus influences cognitive functions and control of food intake. Hippocampi of female rats, either control or ovariectomized, with or without estrogen replacement, were submitted to LC–MS/MS and analysis of pathway‐based functional roles of proteins affected by estrogen deficiency and replacement.
Amanda Paula Pedroso, Adriana Pereira Souza, Guilherme Araújo Câmara, Meira Maria Forcellini Machado, Valter Tadeu Boldarine, Lila Missae Oyama, Mônica Marques Telles, Alexandre Keiji Tashima, Eliane Beraldi Ribeiro   +8 more
wiley   +1 more source

Blockade of FGFR1 Trafficking to the Cell Surface Results in the Partial Mistargeting of the Receptor to Peroxisomes

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Fibroblast growth factor receptor 1 (FGFR1) is co‐translationally integrated into endoplasmic reticulum (ER) membranes and undergoes N‐glycosylation at several positions. This process is essential for FGFR1 progression through the secretory pathway.
Paulina Działek, Aleksandra Chorążewska, Martyna Biaduń, Jian Qiu, Natalia Porębska, Łukasz Opaliński   +5 more
wiley   +1 more source

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]

, 2012
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Kikhney, Alexey, Roermund, Carlo W.T. van,, van Roermund, C. W. T., Opalinski, L., Kikhney, A., Williams, Chris,, de Boer, R., Veenhuis, Marten, Kikhney, Alexey,, de Boer, Rinse, Williams, C., Williams, Chris, Opalinski, Lukasz, Bartoszewska, M., Klei, Ida J. van der,, van der Klei, Ida J., Boer, Rinse de,, Opaliński, Łukasz,, van der Klei, I. J., van Roermund, Carlo W. T., Veenhuis, Marten,, Veenhuis, M., van der Klei, Ida J.; id_orcid, Bartoszewska, Magdalena, Bartoszewska, Magdalena,   +24 more
core   +3 more sources

Airway Involvement in Conradi–Hünermann–Happle Syndrome: A Novel Clinical Manifestation

The Laryngoscope, Volume 136, Issue 7, Page 3240-3245, July 2026.
We report the first documented case of airway involvement in Conradi–Hünermann–Happle syndrome (CDPX2), an X‐linked dominant form of chondrodysplasia punctata caused by pathogenic variants in EBP. A 2‐month‐old female with genetically confirmed CDPX2 developed severe subglottic stenosis and persistent respiratory distress requiring CPAP; cross ...
Enrique G. Villarreal, Jackie Chiang, Evan J. Propst, Nikolaus E. Wolter   +3 more
wiley   +1 more source

The TRIM37 Gene Encodes a Peroxisomal RING-B-Box-Coiled-Coil Protein: Classification of Mulibrey Nanism as a New Peroxisomal Disorder [PDF]

, 2002
Mulibrey nanism is a rare growth disorder of prenatal onset caused by mutations in the TRIM37 gene, which encodes a RING-B-box-coiled-coil protein. The pathogenetic mechanisms of mulibrey nanism are unknown. We have used transiently transfected cells and
Ulmanen, Ismo, Kallijärvi, Jukka, Lipsanen-Nyman, Marita, Lehesjoki, Anna-Elina, Avela, Kristiina   +4 more
core   +1 more source

Metabolic Kinases as Regulators of Inter‐Organelle Communication in Aging and Age‐Related Diseases

Aging Cell, Volume 25, Issue 7, July 2026.
Metabolic kinases integrate cellular energy, nutrient, and stress signals to regulate inter‐organelle coordination during aging. In young or healthy cells, coordinated communication among mitochondria, the endoplasmic reticulum, lysosomes, peroxisomes, and the Golgi apparatus supports calcium handling, lipid metabolism, mitochondrial dynamics ...
Md Riad Chowdhury, Jae‐Han Jeon, Dipanjan Chanda   +2 more
wiley   +1 more source