Results 301 to 310 of about 248,501 (390)

Ubiquitin-specific peptidase 25 ameliorates hepatic steatosis by stabilizing peroxisome proliferator-activated receptor alpha. [PDF]

J Biol Chem
Liu P, Song X, Chen Q, Cen L, Tang C, Yu C, Xu C.   +6 more
europepmc   +1 more source

Pioglitazone Ameliorates Mitochondrial Oxidative Stress and Inflammation via AMPK‐Dependent Inhibition of Mitochondrial Fission in Leigh Syndrome

Cell Proliferation, EarlyView.
Pioglitazone suppresses mitochondrial excessive ROS generation and COX‐2 level through inhibition of Drp‐1 mediated mitochondrial fission in an AMPK‐dependent manner in LS. ABSTRACT Loss of function mutations of NDUFS4 resulted in Leigh syndrome, which is a progressive neurodegenerative disease and characterized by mitochondrial oxidative stress ...
Jie Luo, Ling Chen, Xiaoxian Zhang, Qiang Su, Xiaoya Zhou, Qizhou Lian   +5 more
wiley   +1 more source

Peroxisome proliferator-activated receptor agonists: A new hope towards the management of alcoholic liver disease. [PDF]

World J Gastroenterol
Durairajan SSK, Singh AK, Iyaswamy A.
europepmc   +1 more source

Atopic Dermatitis (AD) Related Cord Blood DNA Methylation Patterns Are Linked to Maternal AD

Allergy, EarlyView.
Laura Matzner, Johanna Denkena, Marey Messingschlager, Anke Seegebarth, Rosa Engelhardt, Zhuoxin Peng, Parastoo Kheiroddin, Sebastian D. Mackowiak, Hermann Brenner, Dietrich Rothenbacher, Naveed Ishaque, Michael Kabesch, Roland Eils, Jon Genuneit, Saskia Trump, Irina Lehmann   +15 more
wiley   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, EarlyView.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Compound 3d Attenuates Metabolic Dysfunction-Associated Steatohepatitis via Peroxisome Proliferator-Activated Receptor Pathway Activation and Inhibition of Inflammatory and Apoptotic Signaling. [PDF]

Metabolites
Zhang S, Yu J, Bai S, Li S, Qiu Q, Kong X, Xiang C, Liu Z, Yu P, Teng Y.   +9 more
europepmc   +1 more source

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

Peroxisome Proliferator-Activated Receptor Gamma Regulates Interleukin-6-Induced Lipoprotein (a) Gene Expression in Human HepG2 Cells. [PDF]

J Cardiovasc Pharmacol
Harb T, Ziogos E, Amat-Alarcon N, Lai S, Gerstenblith G, Arvanitis M, Leucker TM.   +6 more
europepmc   +1 more source

Peroxisome proliferator-activated receptors in metabolic and renal health: a comprehensive review

Nazmi Vahora, Meenakshi Reddy Yathindra, Deepa Maria James, Rahul Sharma, Ajit Sneha Shrikant Panvalkar, G. Shyam, N. L. Swathi   +6 more
openalex   +2 more sources

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source