Results 71 to 80 of about 606,469 (298)
Modeling the imported malaria to north Africa and the absorption effect of the immigrants
Mathematical Biosciences and Engineering, 2019 As Malaria represents one of the major health burdens in Africa, there is a risk of reappearance of this vector-borne disease in malaria-free or low risk countries such as those in North Africa.
Souâd Yacheur +2 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Bordetella petrii Infection with Long-lasting Persistence in Human
Emerging Infectious Diseases, 2011 We report the repeated isolation of Bordetella petrii in the sputum of a 79-year-old female patient with diffuse bronchiectasis and persistence of the bacterium for >1 year.
Alain Le Coustumier +4 more
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Revista Brasileira de Zootecnia, 2008 Neste trabalho, objetivou-se verificar a resposta de populações de alfafa à desfolhação. Avaliaram-se duas populações de alfafa Crioula (tipo-feno), selecionada em estádio de plântula de acordo com o comprimento do segundo entrenó (EC = 1,5 cm; EL = 2,5 ...
Daniela Favero +3 more
doaj +1 more source
Measuring the Conformation and Persistence Length of Single-Stranded DNA Using a DNA Origami Structure [PDF]
, 2018 Efrat Roth +4 more
openalex +1 more source
EXTH-33. PRIMING OF SYNNOTCH CAR T CELLS VIA CNS-SPECIFIC ANTIGEN ALLOWS SPATIAL AND TEMPORAL REGULATION OF CAR EXPRESSION, EFFECTIVE HOMING AND PERSISTENCE OF T CELLS IN THE CNS [PDF]
, 2022 Payal Watchmaker +7 more
openalex +1 more source