Results 121 to 130 of about 464,947 (293)

Concept and Characteristic of Urban Landscape Layering, and Design Approach Towards Urban Regeneration

open access: yesFengjing Yuanlin
ObjectiveContemporary urban landscape is heterogeneous, whose regeneration is grounded in a thorough examination of historical landscape evolution within a broader regional context.
Jinyu ZHANG, Yuan XU, Yufan ZHU
doaj   +1 more source

Medium‐Entropy Engineering Enhances Na⁺/Electron Transport in Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs Cathode for Sodium‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
This study proposes a medium‐entropy strategy to enhance sodium vanadium fluorophosphate cathodes. The designed Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs composite enhances structural stability and charge transport. Entropy‐induced distortion and carbon nanotubes (CNTs) synergistically improve Na⁺/electron kinetics. In situ XRD reveals a reversible dual‐
Ju Yang   +7 more
wiley   +1 more source

Discontinuity of Sacubitril/Valsartan in a Cohort of Hospitalised Individuals for Heart Failure

open access: yesEpidemiology, Biostatistics and Public Health
INTRODUCTION Heart failure (HF) is a complex, multifactorial clinical syndrome that originates from an alteration in the pump function of the heart, either systolic and/or diastolic.
Davide Soranna   +3 more
doaj   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

open access: yesAdvanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao   +14 more
wiley   +1 more source

PEDOT: PSS‐Enabled CNT and Bi0.5Sb1.5Te3 Interface Microengineering for Integrated Thermoelectric Energy Harvesting and Corrosion Protection in Cementitious Composite

open access: yesAdvanced Science, EarlyView.
In this study, PP and BST are used to synergistically enhance the dispersibility and thermoelectric performance of CNT cementitious materials. Further Author Manuscript research shows that the composite material maintains >80% compressive strength and chloride resistance performance at −20 or 70°C.
Chen Zhang   +6 more
wiley   +1 more source

SpaBatch: Deep Learning‐Based Cross‐Slice Integration and 3D Spatial Domain Identification in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
SpaBatch is an end‐to‐end multi‐slice spatial transcriptomics data integration framework. It simultaneously performs embedding learning, spatial feature denoising and reconstruction, batch effect correction, and spatial domain optimization, effectively correcting batch effects and achieving accurate 3D spatial domain identification.
Jinyun Niu   +5 more
wiley   +1 more source

Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium

open access: yesAdvanced Science, EarlyView.
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion, followed by delayed invasion with matrix reorganization and proliferation.
Kabilan Sakthivel   +8 more
wiley   +1 more source

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

open access: yesAdvanced Science, EarlyView.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng   +6 more
wiley   +1 more source

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