Results 181 to 190 of about 16,153 (254)

Analysis of Lactation Performance and Mastitis Incidence in High- and Low-Yielding Dairy Cows Using DHI Data. [PDF]

Animals (Basel)
Zhou Q, Geng Z, Lian S, Wang J, Wu R.
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Genetic Insights: Balancing Milk Yield, Fat: Protein Ratio and Fertility in Primiparous Cows From Subtropical Regions. [PDF]

J Anim Breed Genet
Evangelista AF, Valloto AA, El Faro L, Pereira RJ, Dias LT, de Almeida Teixeira R.   +5 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Neuromorphic Photoresponse in Ultrathin SnS₂-Based Field Effect Transistor. [PDF]

ACS Appl Mater Interfaces
De Stefano S, Durante O, Sessa A, Politano A, D'Olimpio G, Dadiani T, Faella E, Dinescu A, Parvulescu C, Hetherington C, Kuo CN, Lue CS, Aldrigo M, Passacantando M, Di Bartolomeo A.   +14 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

World and Human Action Models towards gameplay ideation. [PDF]

Nature
Kanervisto A, Bignell D, Wen LY, Grayson M, Georgescu R, Valcarcel Macua S, Tan SZ, Rashid T, Pearce T, Cao Y, Lemkhenter A, Jiang C, Costello G, Gupta G, Tot M, Ishida S, Gupta T, Arora U, White RW, Devlin S, Morrison C, Hofmann K.   +21 more
europepmc   +1 more source

Subnational analysis of pediatric sepsis incidence and mortality from official records in Chile and Mexico: a longitudinal study from 2014 to 2024. [PDF]

BMC Public Health
Gatica S, Caporal P, Diaz F, Jabornisky R, Simon F, Kissoon N.   +5 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Association Between the Persistency and Severity of Mitral Regurgitation and the Hematologic Z-Values of Inflammatory Biomarkers in Kawasaki Disease. [PDF]

Korean Circ J
Lee JS, Lee SY, Lee J, Jang GY, Kim WY, Ha KS.   +5 more
europepmc   +1 more source