Results 61 to 70 of about 59,437 (308)

Inhibition of Small-Conductance Calcium-Activated Potassium Current (I_K,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation

, 2021
Background: Small-conductance Ca2+-activated K+ (KCa2) channels have been proposed as a possible atrial-selective target to pharmacologically terminate atrial fibrillation (AF) and to maintain sinus rhythm.
Smerup, M., Diness, J.G., Buhl, R., Sattler, S., Jespersen, Thomas, Sattler, Stefan, Kuiper, M., Gatta, Giulia, Adler, Ditte M.T., Van Hunnik, A., Schotten, Ulrich, Van Hunnik, Arne, Hesselkilde, Eva Melis, Sørensen, Ulrik, Gatta, G., Fenner, Merle Friederike, Adler, D.M.T., Jespersen, T., Hesselkilde, E.M., Sorensen, U., Schotten, U., Smerup, Morten, Fenner, M.F., Diness, Jonas Goldin, Verheule, S., Buhl, Rikke, Kuiper, Marion, Verheule, Sander   +27 more
core   +1 more source

Catheter ablation in patients with persistent atrial fibrillation [PDF]

European Heart Journal, 2016
Catheter ablation is increasingly offered to patients who suffer from symptoms due to atrial fibrillation (AF), based on a growing body of evidence illustrating its efficacy compared with antiarrhythmic drug therapy. Approximately one-third of AF ablation procedures are currently performed in patients with persistent or long-standing persistent AF ...
Kirchhof, Paulus, Calkins, Hugh
openaire   +2 more sources

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Catheter Ablation versus Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation (CASA-AF): study protocol for a randomised controlled trial

Trials, 2018
Background Atrial fibrillation is the commonest arrhythmia which raises the risk of heart failure, thromboembolic stroke, morbidity and death. Pharmacological treatments of this condition are focused on heart rate control, rhythm control and reduction in
Habib Rehman Khan, Ines Kralj-Hans, Shouvik Haldar, Toufan Bahrami, Jonathan Clague, Anthony De Souza, Darrel Francis, Wajid Hussain, Julian Jarman, David Gareth Jones, Neeraj Mediratta, Raad Mohiaddin, Tushar Salukhe, Simon Jones, Joanne Lord, Caroline Murphy, Joanna Kelly, Vias Markides, Dhiraj Gupta, Tom Wong   +19 more
doaj   +1 more source

Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the efficacy and safety of guselkumab, an interleukin‐23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor (TNF) inhibitor.
Alexis Ogdie, Joseph F. Merola, Philip J. Mease, Christopher T. Ritchlin, Jose U. Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D. Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B. Gottlieb   +12 more
wiley   +1 more source

Catheter ablation of persistent and long-standing persistent atrial fibrillation. Strategies and results

, 2013
Catheter ablation for paroxysmal atrial fibrillation is a meanwhile established therapy option, which is most frequently performed using radiofrequency ablation. Mid-term success rate of 70 % are achievable with a single ablation procedure.
Steven, Daniel, Lüker, Jakob, Willems, Stephan, Servatius, Helge, Hoffmann, Boris, Sultan, Arian, Schäffer, Benjamin   +6 more
core   +1 more source

Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study [PDF]

, 2013
This work was supported by the British Heart Foundation PG/10/37/28347, RG/10/11/28457, NIHR Biomedical Research Centre funding, and the ElectroCardioMaths Programme of the Imperial BHF Centre of Research ...
Peters, NS, Petersen, SE, Kojodjojo, P., Quest, R, Hunter, R., Petersen, S.E., Karim, R, Quest, R., Lim, PB, Ariff, B., Francis, D.P., Malcolme-Lawes, L.C., Kanagaratnam, P., Juli, C., Schilling, R, Karim, R., Boubertakh, R., Schilling, R., Bai, W, Lim, P.B., Francis, DP, Jamil-Copley, S., Peters, N.S., Rueckert, D, Kanagaratnam, P, Bai, W., Malcolme-Lawes, LC, Davies, D.W., Davies, DW, Boubertakh, R, Jones, D., Juli, C, Kojodjojo, P, Hunter, R, Rueckert, D., Jamil-Copley, S, Ariff, B, Jones, D   +37 more
core   +1 more source

Nonadherence and uncontrolled arterial hypertension in Croatia—Insights from the May Measurement Month 2023 campaign and Hunting the silent killer programme

British Journal of Clinical Pharmacology, EarlyView.
Aims To determine the prevalence of non‐adherence to antihypertensive medicines and to identify demographic and behavioral factors associated with non‐adherence in subjects enrolled in the May Measurement Month (MMM) 2023, as part of the permanent public health action Hunting the silent killer.
Valerija Bralić Lang, Ana Soldo, Olgica Velkovski Škopić, Sunčana Vlah Tomičević, Tin Šaban, Andrej Belančić, Ana Jelaković, Josipa Josipović, Mihaela Marinović Glavić, Ivan Pećin, Luka Prgomet, Tajana Željković Vrkić, Bojan Jelaković   +12 more
wiley   +1 more source

Mobile app-based symptom-rhythm correlation assessment in patients with persistent atrial fibrillation [PDF]

, 2022
Background: The assessment of symptom-rhythm correlation (SRC) in patients with persistent atrial fibrillation (AF) is challenging. Therefore, we performed a novel mobile app-based approach to assess SRC in persistent AF.Methods: Consecutive persistent ...
Konstanze Betz, Jonas L. Isaksen, Kantes, Jorgen, van der Velden, Rachel M. J., Isaksen, Jonas L, Astrid N.L. Hermans, Van Gelder, Isabelle C, Isabelle C. Van Gelder, Slegers, Daniek P J, Nguyen, Hien L., Hendriks, Jeroen M, Rienstra, Michiel, den Uijl, Dennis W, Nguyen, Hien L, Kevin Vernooy, Dominik Linz, Linz, Dominik, Betz, Konstanze, Hendriks, Jeroen M., Michiel Rienstra, Pluymaekers, Nikki A H A, Baumert, Mathias, Gawalko, Monika, Gelder, Isabelle C. Van, Nora Andelfinger, Verhaert, Dominique V. M., Vernooy, Kevin, Hien L. Nguyen, Isaksen, Jonas L., Nikki A.H.A. Pluymaekers, Pluymaekers, Nikki A. H. A., Kanters, Jurgen K., Justin G.L.M. Luermans, Jørgen K. Kanters, van der Velden, Rachel M J, Slegers, Daniek P. J., Hermans, Astrid N L, Vernooy, Kevin; id_orcid, den Uijl, Dennis W., Daniek P.J. Slegers, Andelfinger, Nora, Luermans, Justin G L M, Kanters, Jørgen K, Stijn Evens, Rienstra, Michiel; id_orcid, Verhaert, Dominique V M, Evens, Stijn, Monika Gawalko, Dominique V.M. Verhaert, Luermans, Justin G. L. M., Hermans, Astrid N. L., Dennis W. den Uijl, Jeroen M. Hendriks, Rachel M.J. van der Velden, Hendriks, Jeroen M; id_orcid, Mathias Baumert   +55 more
core   +1 more source

Effect of sacubitril/valsartan on sinus rhythm maintenance after catheter ablation in patients with persistent atrial fibrillation without reduced ejection fraction heart failure: a study protocol for a multi-center, open-label, randomized, controlled, superiority clinical trial

Frontiers in Cardiovascular Medicine
IntroductionA high recurrence rate of atrial fibrillation was monitored after catheter ablation for persistent atrial fibrillation. Sacubitril/valsartan can improve outcomes for patients with heart failure and ventricular tachycardia, but few studies ...
Ruowu Qiu, Ruowu Qiu, Qingqing Ni, Qingqing Ni, Muli Wu, Muli Wu, Zhongbo Xiao, Zhongbo Xiao, Jiaxin Xiao, Jiaxin Xiao, Weizhao Lin, Weipeng Huang, Yequn Chen, Yequn Chen, Chang Chen, Chang Chen, Liekai Hong, Liekai Hong, Liekai Hong   +18 more
doaj   +1 more source