Results 141 to 150 of about 54,259 (246)

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

The fiber of persistent homology for trees. [PDF]

J Appl Comput Topol
Beers D, Leygonie J.
europepmc   +1 more source

Tight basis cycle representatives for persistent homology of large biological data sets. [PDF]

PLoS Comput Biol, 2023
Aggarwal M, Periwal V.
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Persistent Homology Classifies Parameter Dependence of Patterns in Turing Systems. [PDF]

Bull Math Biol
Spector R, Harrington HA, Gaffney EA.
europepmc   +1 more source

The robustness of persistent homology of brain networks to data acquisition-related non-neural variability in resting state fMRI. [PDF]

Hum Brain Mapp, 2023
Kumar S, Shovon AR, Deshpande G.
europepmc   +1 more source

Persistent Relative Homology for Topological Data Analysis

A central problem in data-driven scientific inquiry is how to interpret structure in noisy, high-dimensional data. Topological data analysis (TDA) provides a solution via the language of persistent homology, which encodes features of interest as holes ...
Lentz, Christian J
core  

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Probing omics data via harmonic persistent homology. [PDF]

Sci Rep
Gurnari D, Guzmán-Sáenz A, Utro F, Bose A, Basu S, Parida L.   +5 more
europepmc   +1 more source

Dynamic ECG signal quality evaluation based on persistent homology and GoogLeNet method. [PDF]

Front Neurosci, 2023
Ren Y, Liu F, Xia S, Shi S, Chen L, Wang Z.   +5 more
europepmc   +1 more source