Results 211 to 220 of about 1,043,448 (307)

Colony Binary Classification Based on Persistent Homology Feature Extraction and Improved EfficientNet. [PDF]

Bioengineering (Basel)
Wang Z, Yang K, Tang J, Gao J, Zhang Y, Xu W, Huang CM.   +6 more
europepmc   +1 more source

Method for persistent topological features extraction of schizophrenia patients' electroencephalography signal based on persistent homology. [PDF]

Front Comput Neurosci, 2022
Guo G, Zhao Y, Liu C, Fu Y, Xi X, Jin L, Shi D, Wang L, Duan Y, Huang J, Tan S, Yin G.   +11 more
europepmc   +1 more source

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

Advanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang, Wenkai Wang, Zhenling Peng, Jianyi Yang   +3 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Identifying key genes in cancer networks using persistent homology. [PDF]

Sci Rep
Ramos RH, Bardelotte YA, de Oliveira Lage Ferreira C, Simao A.   +3 more
europepmc   +1 more source

A Topological Loss Function for Deep-Learning Based Image Segmentation Using Persistent Homology. [PDF]

IEEE Trans Pattern Anal Mach Intell, 2022
Clough JR, Byrne N, Oksuz I, Zimmer VA, Schnabel JA, King AP.   +5 more
europepmc   +1 more source

TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNA

Advanced Science, EarlyView.
We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li, Jia‐Hui Huang, Jin‐E Yang, Yi‐Hang Li, Juan‐Zhen Hong, Ting‐Ting Wang, Ying‐Lei Chi, Meng‐Zhi Wu, Wei Wang, Ying Zhu, Shi‐Mei Zhuang   +10 more
wiley   +1 more source

Filipino sign language alphabet recognition using Persistent Homology Classification algorithm. [PDF]

PeerJ Comput Sci
Jetomo CB, De Lara MLD.
europepmc   +1 more source

0-Dimensional Persistent Homology Analysis Implementation in Resource-Scarce Embedded Systems. [PDF]

Sensors (Basel), 2022
Branco S, Carvalho JG, Reis MS, Lopes NV, Cabral J.   +4 more
europepmc   +1 more source

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source