Results 41 to 50 of about 7,443,031 (227)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Empirical assessment of functional somatic disorder (FSD): frequency, applicability, and diagnostic refinement in a population-based sample

BMC Medicine
Background Persistent and troublesome physical symptoms are common and can, regardless of their cause, greatly impair patients’ quality of life. Reflecting complex brain-body interactions, they are observed across all healthcare specialties, commonly ...
Abigail Smakowski, Judith Rosmalen, Bernd Löwe, Christopher Burton, Anne Toussaint   +4 more
doaj   +1 more source

Efficacy of a mechanism-based psychological intervention for persistent gastrointestinal symptoms in ulcerative colitis and irritable bowel syndrome: results of a three-arm randomised controlled trial (SOMA.GUT-RCT)Research in context

EClinicalMedicine
Summary: Background: Irritable Bowel Syndrome (IBS) and Ulcerative Colitis (UC) are chronic gastrointestinal conditions with differing pathologies but overlapping symptoms and shared risk factors contributing to symptom persistence.
Kerstin Maehder, Luisa Peters, Sina Hübener, Anna Matysiak, Samuel Huber, Anne Toussaint, Antonia Zapf, Eik Vettorazzi, Philipp Weber, Katharina Stahlmann, Viola Andresen, Yvonne Nestoriuc, Ansgar W. Lohse, Bernd Löwe   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Older Breast Cancer Survivors: Factors Associated with Self-reported Symptoms of Persistent Lymphedema Over 7 years of Follow-up [PDF]

, 2010
Lymphedema of the arm is a common complication of breast cancer with symptoms that can persist over long periods of time. For older women (over 50% of breast cancer cases) it means living with the potential for long-term complications of persistent ...
Patricia A. Ganz, Kerri M. Clough-Gorr, Clough-Gorr, Kerri M, Ganz, Patricia A, Silliman, Rebecca A, Rebecca A. Silliman   +5 more
core   +3 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Persistent COVID-19 symptoms 1 year after hospital discharge: A prospective multicenter study

PLoS ONE, 2022
Objective To determine the health status and exercise capacity of COVID-19 survivors one year after hospital discharge. Methods This multicenter prospective study included COVID-19 survivors 12 months after hospital discharge.
Judit Aranda, Isabel Oriol, Lucía Feria, Gabriela Abelenda, Alexander Rombauts, Antonella Francesca Simonetti, Clarisa Catalano, Natàlia Pallarès, Miguel Martín, Núria Vàzquez, Estel Vall-Llosera, Nicolás Rhyman, Romina Concepción Suárez, Marta Nogué, Jose Loureiro-Amigo, Ana Coloma, Luis Ceresuela, Jordi Carratalà   +17 more
doaj   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Depressive symptoms in cancer patients compared with people from the general population: the role of sociodemographic and medical factors [PDF]

, 2003
This study examined depressive symptoms in 475 patients with cancer and in a reference group of 255 individuals without cancer from the general population and the associations of those symptoms with sociodemographic and medical factors.
Schroevers, M.J., Schroevers, M.J.; id_orcid, Sanderman, R., Ranchor, A.V.   +3 more
core   +2 more sources

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source