Results 131 to 140 of about 2,065,251 (228)

Early identification of persistent somatic symptoms in primary care: data-driven and theory-driven predictive modelling based on electronic medical records of Dutch general practices. [PDF]

BMJ Open, 2023
Kitselaar WM, Büchner FL, van der Vaart R, Sutch SP, Bennis FC, Evers AW, Numans ME.   +6 more
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Network analysis in adolescent patients with somatic symptom disorders

BMC Psychiatry
Background Somatic symptom disorder (SSD) is one of the most common conditions in adolescents. Persistent symptoms are closely associated with impaired academic performance, reduced social functioning, high healthcare utilization, and increased risk of ...
Doudou Zheng, Shijian Wang, Jingya Li, Linghua Kong, Lin Zhao, Ying Yang   +5 more
doaj   +1 more source

Correction to: The general practitioners perspective regarding registration of persistent somatic symptoms in primary care: a survey. [PDF]

BMC Fam Pract, 2021
Kitselaar WM, van der Vaart R, van Tilborg-den Boeft M, Vos HMM, Numans ME, Evers AWM.   +5 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The general practitioners perspective regarding registration of persistent somatic symptoms in primary care: a survey. [PDF]

BMC Fam Pract, 2021
Kitselaar WM, van der Vaart R, van Tilborg-den Boeft M, Vos HMM, Numans ME, Evers AWM.   +5 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Pain, Fatigue and Persistent Somatic Symptoms: Translation from Scientific research to Clinical practice

The focus of this presentation is the translation of scientific research on pain, fatigue and persistent somatic symptoms into clinical practice. We focus on the scientific background leading to an integrative working model.
BOGAERTS, Katleen
core   +1 more source

Perceived working mechanisms of psychosomatic therapy in patients with persistent somatic symptoms in primary care: a qualitative study. [PDF]

BMJ Open, 2022
Wortman MSH, Olde Hartman TC, van der Wouden JC, Dankers S, Visser B, Assendelft WJJ, van der Horst HE.   +6 more
europepmc   +1 more source