Results 231 to 240 of about 1,288,582 (274)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

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Isosceles Constraints for Person Re-Identification

IEEE Transactions on Image Processing, 2020
In the existing works of person re-identification (ReID), batch hard triplet loss has achieved great success. However, it only cares about the hardest samples within the batch. For any probe, there are massive mismatched samples (crucial samples) outside the batch which are closer than the matched samples.
Furong Xu, Bingpeng Ma, Hong Chang, Shiguang Shan   +3 more
openaire   +2 more sources

Unsupervised Person Re-identification

ACM Transactions on Multimedia Computing, Communications, and Applications, 2018
The superiority of deeply learned pedestrian representations has been reported in very recent literature of person re-identification (re-ID). In this article, we consider the more pragmatic issue of learning a deep feature with no or only a few labels.
Hehe Fan, Liang Zheng, Chenggang Yan, Yi Yang   +3 more
openaire   +1 more source

Partial Person Re-Identification

2015 IEEE International Conference on Computer Vision (ICCV), 2015
We address a new partial person re-identification (re-id) problem, where only a partial observation of a person is available for matching across different non-overlapping camera views. This differs significantly from the conventional person re-id setting where it is assumed that the full body of a person is detected and aligned.
Wei-Shi Zheng, Xiang Li, Tao Xiang, Shengcai Liao, Jianhuang Lai, Shaogang Gong   +5 more
openaire   +1 more source

Fast Open-World Person Re-Identification

IEEE Transactions on Image Processing, 2018
Existing person re-identification (re-id) methods typically assume that: 1) any probe person is guaranteed to appear in the gallery target population during deployment (i.e., closed-world) and 2) the probe set contains only a limited number of people (i.e., small search scale).
Xiatian Zhu, Botong Wu, Dongcheng Huang, Wei-Shi Zheng   +3 more
openaire   +2 more sources

Face in Person Re-Identification

2014
The face represents one of the most diffused and established biometrics for both identity verification and recognition with a large corpus of research focused on advancing the accuracy, the robustness, and the response speed of face recognition systems by means of 2D, 3D, and hybrid approaches.
Abate, Andrea F., RICCIARDI, STEFANO, Tortora, Genoveffa   +2 more
openaire   +2 more sources