Results 141 to 150 of about 104,754 (312)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Personas que conectan con personas :

open access: yes
En Publicidad y Relaciones Públicas, no basta con saber comunicar; hay que conectar. La Inteligencia Emocional es una competencia clave en este ámbito, pero su enseñanza sigue siendo una asignatura pendiente en la universidad. Para abordar esta carencia, se diseña un manual educativo que integra la Inteligencia Emocional como una competencia esencial ...
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Drug screening in human plasma by cloud-point extraction and HPLC

open access: yesOpen Chemistry, 2013
Madej Katarzyna, Persona Karolina
doaj   +1 more source

Explainable AI-driven precision clinical trial enrichment: demonstration of the NetraAI platform with a phase II depression trial. [PDF]

open access: yesNPJ Digit Med
Geraci J   +8 more
europepmc   +1 more source

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